Daily Papers

AI agents hold growing promise for accelerating scientific discovery; yet, a lack of frontier evaluations hinders adoption into real workflows. Expert-written benchmarks have proven effective at measuring AI reasoning, but most at this stage have become saturated and only measure performance on constrained outputs. To help address this gap, we introduce COMPOSITE-STEM, a benchmark of 70 expert-written tasks in physics, biology, chemistry, and mathematics, curated by doctoral-level researchers. Our benchmark combines exact-match grading and criterion-based rubrics with an LLM-as-a-jury grading protocol, allowing more flexible assessment of scientifically meaningful outputs. Using an adapted multimodal Terminus-2 agent harness within the Harbor agentic evaluation framework, we evaluate four frontier models. The top-performing model achieves 21%, demonstrating that COMPOSITE-STEM captures capabilities beyond current agent reach. All tasks are open-sourced with contributor permission to support reproducibility and to promote additional research towards AI's acceleration of scientific progress in these domains.

Terminals provide a powerful interface for AI agents by exposing diverse tools for automating complex workflows, yet existing terminal-agent benchmarks largely focus on tasks grounded in text, code, and structured files. However, many real-world workflows require practitioners to work directly with audio and video files. Working with such multimedia files calls for terminal agents not only to understand multimedia content, but also to convert auditory and visual evidence across related files into appropriate actions. To evaluate terminal agents on multimedia-file tasks, we introduce MultiMedia-TerminalBench (MMTB), a benchmark of 105 tasks across 5 meta-categories where terminal agents directly operate with audio and video files. Alongside MMTB, we propose Terminus-MM, a multimedia harness that extends Terminus-KIRA with audio and video perception for terminal agents. Together, MMTB and Terminus-MM support a controlled study of multimedia terminal agents, revealing how different forms of multimedia access shape task outcomes and determine which evidence agents rely on to construct executable terminal workflows. MMTB media and metadata are released at https://huggingface.co/datasets/mm-tbench/mmtb-media

A multimodal AI agent is characterized by its ability to process and learn from various types of data, including natural language, visual, and audio inputs, to inform its actions. Despite advancements in large language models that incorporate visual data, such as GPT-4V, effectively translating image-based data into actionable outcomes for AI agents continues to be challenging. In this paper, we introduce a multimodal model that incorporates the concept of functional token specifically designed for AI agent applications. To ensure compatibility with edge devices, our model is optimized to a compact size of less than 1B parameters. Like GPT-4, our model can process both English and Chinese. We demonstrate that this model is capable of operating efficiently on a wide range of edge devices, including as constrained as a Raspberry Pi.

While Multi-Agent Systems (MAS) show potential for complex clinical decision support, the field remains hindered by architectural fragmentation and the lack of standardized multimodal integration. Current medical MAS research suffers from non-uniform data ingestion pipelines, inconsistent visual-reasoning evaluation, and a lack of cross-specialty benchmarking. To address these challenges, we present MedMASLab, a unified framework and benchmarking platform for multimodal medical multi-agent systems. MedMASLab introduces: (1) A standardized multimodal agent communication protocol that enables seamless integration of 11 heterogeneous MAS architectures across 24 medical modalities. (2) An automated clinical reasoning evaluator, a zero-shot semantic evaluation paradigm that overcomes the limitations of lexical string-matching by leveraging large vision-language models to verify diagnostic logic and visual grounding. (3) The most extensive benchmark to date, spanning 11 organ systems and 473 diseases, standardizing data from 11 clinical benchmarks. Our systematic evaluation reveals a critical domain-specific performance gap: while MAS improves reasoning depth, current architectures exhibit significant fragility when transitioning between specialized medical sub-domains. We provide a rigorous ablation of interaction mechanisms and cost-performance trade-offs, establishing a new technical baseline for future autonomous clinical systems. The source code and data is publicly available at: https://github.com/NUS-Project/MedMASLab/

With the advancement of Multimodal Large Language Models (MLLM), LLM-driven visual agents are increasingly impacting software interfaces, particularly those with graphical user interfaces. This work introduces a novel LLM-based multimodal agent framework for mobile devices. This framework, capable of navigating mobile devices, emulates human-like interactions. Our agent constructs a flexible action space that enhances adaptability across various applications including parser, text and vision descriptions. The agent operates through two main phases: exploration and deployment. During the exploration phase, functionalities of user interface elements are documented either through agent-driven or manual explorations into a customized structured knowledge base. In the deployment phase, RAG technology enables efficient retrieval and update from this knowledge base, thereby empowering the agent to perform tasks effectively and accurately. This includes performing complex, multi-step operations across various applications, thereby demonstrating the framework's adaptability and precision in handling customized task workflows. Our experimental results across various benchmarks demonstrate the framework's superior performance, confirming its effectiveness in real-world scenarios. Our code will be open source soon.

Long-horizon multimodal agents depend on external memory; however, similarity-based retrieval often surfaces stale, low-credibility, or conflicting items, which can trigger overconfident errors. We propose Multimodal Memory Agent (MMA), which assigns each retrieved memory item a dynamic reliability score by combining source credibility, temporal decay, and conflict-aware network consensus, and uses this signal to reweight evidence and abstain when support is insufficient. We also introduce MMA-Bench, a programmatically generated benchmark for belief dynamics with controlled speaker reliability and structured text-vision contradictions. Using this framework, we uncover the "Visual Placebo Effect", revealing how RAG-based agents inherit latent visual biases from foundation models. On FEVER, MMA matches baseline accuracy while reducing variance by 35.2% and improving selective utility; on LoCoMo, a safety-oriented configuration improves actionable accuracy and reduces wrong answers; on MMA-Bench, MMA reaches 41.18% Type-B accuracy in Vision mode, while the baseline collapses to 0.0% under the same protocol. Code: https://github.com/AIGeeksGroup/MMA.

Multimodality-to-Multiaudio (MM2MA) generation faces significant challenges in synthesizing diverse and contextually aligned audio types (e.g., sound effects, speech, music, and songs) from multimodal inputs (e.g., video, text, images), owing to the scarcity of high-quality paired datasets and the lack of robust multi-task learning frameworks. Recently, multi-agent system shows great potential in tackling the above issues. However, directly applying it to MM2MA task presents three critical challenges: (1) inadequate fine-grained understanding of multimodal inputs (especially for video), (2) the inability of single models to handle diverse audio events, and (3) the absence of self-correction mechanisms for reliable outputs. To this end, we propose AudioGenie, a novel training-free multi-agent system featuring a dual-layer architecture with a generation team and a supervisor team. For the generation team, a fine-grained task decomposition and an adaptive Mixture-of-Experts (MoE) collaborative entity are designed for dynamic model selection, and a trial-and-error iterative refinement module is designed for self-correction. The supervisor team ensures temporal-spatial consistency and verifies outputs through feedback loops. Moreover, we build MA-Bench, the first benchmark for MM2MA tasks, comprising 198 annotated videos with multi-type audios. Experiments demonstrate that our AudioGenie outperforms state-of-the-art (SOTA) methods across 9 metrics in 8 tasks. User study further validate the effectiveness of the proposed method in terms of quality, accuracy, alignment, and aesthetic. The anonymous project website with samples can be found at https://audiogenie.github.io/.

Large Multimodal Models (LMMs) have ushered in a new era in artificial intelligence, merging capabilities in both language and vision to form highly capable Visual Foundation Agents. These agents are postulated to excel across a myriad of tasks, potentially approaching general artificial intelligence. However, existing benchmarks fail to sufficiently challenge or showcase the full potential of LMMs in complex, real-world environments. To address this gap, we introduce VisualAgentBench (VAB), a comprehensive and pioneering benchmark specifically designed to train and evaluate LMMs as visual foundation agents across diverse scenarios, including Embodied, Graphical User Interface, and Visual Design, with tasks formulated to probe the depth of LMMs' understanding and interaction capabilities. Through rigorous testing across nine proprietary LMM APIs and eight open models, we demonstrate the considerable yet still developing agent capabilities of these models. Additionally, VAB constructs a trajectory training set constructed through hybrid methods including Program-based Solvers, LMM Agent Bootstrapping, and Human Demonstrations, promoting substantial performance improvements in LMMs through behavior cloning. Our work not only aims to benchmark existing models but also provides a solid foundation for future development into visual foundation agents. Code, train \& test data, and part of fine-tuned open LMMs are available at https://github.com/THUDM/VisualAgentBench.

Multi-Modal Large Language Models (MLLMs), despite being successful, exhibit limited generality and often fall short when compared to specialized models. Recently, LLM-based agents have been developed to address these challenges by selecting appropriate specialized models as tools based on user inputs. However, such advancements have not been extensively explored within the medical domain. To bridge this gap, this paper introduces the first agent explicitly designed for the medical field, named Multi-modal Medical Agent (MMedAgent). We curate an instruction-tuning dataset comprising six medical tools solving seven tasks across five modalities, enabling the agent to choose the most suitable tools for a given task. Comprehensive experiments demonstrate that MMedAgent achieves superior performance across a variety of medical tasks compared to state-of-the-art open-source methods and even the closed-source model, GPT-4o. Furthermore, MMedAgent exhibits efficiency in updating and integrating new medical tools. Codes and models are all available.

We introduce Kimi K2.5, an open-source multimodal agentic model designed to advance general agentic intelligence. K2.5 emphasizes the joint optimization of text and vision so that two modalities enhance each other. This includes a series of techniques such as joint text-vision pre-training, zero-vision SFT, and joint text-vision reinforcement learning. Building on this multimodal foundation, K2.5 introduces Agent Swarm, a self-directed parallel agent orchestration framework that dynamically decomposes complex tasks into heterogeneous sub-problems and executes them concurrently. Extensive evaluations show that Kimi K2.5 achieves state-of-the-art results across various domains including coding, vision, reasoning, and agentic tasks. Agent Swarm also reduces latency by up to 4.5times over single-agent baselines. We release the post-trained Kimi K2.5 model checkpoint to facilitate future research and real-world applications of agentic intelligence.

Multimodal large language models (MLLMs) that integrate visual and textual reasoning leverage chain-of-thought (CoT) prompting to tackle complex visual tasks, yet continue to exhibit visual hallucinations and an over-reliance on textual priors. We present a systematic diagnosis of state-of-the-art vision-language models using a three-stage evaluation framework, uncovering key failure modes. To address these, we propose an agent-based architecture that combines LLM reasoning with lightweight visual modules, enabling fine-grained analysis and iterative refinement of reasoning chains. Our results highlight future visual reasoning models should focus on integrating a broader set of specialized tools for analyzing visual content. Our system achieves significant gains (+10.3 on MMMU, +6.0 on MathVista over a 7B baseline), matching or surpassing much larger models. We will release our framework and evaluation suite to facilitate future research.

Multimodal molecular models often suffer from 3D conformer unreliability and modality collapse, limiting their robustness and generalization. We propose MuMo, a structured multimodal fusion framework that addresses these challenges in molecular representation through two key strategies. To reduce the instability of conformer-dependent fusion, we design a Structured Fusion Pipeline (SFP) that combines 2D topology and 3D geometry into a unified and stable structural prior. To mitigate modality collapse caused by naive fusion, we introduce a Progressive Injection (PI) mechanism that asymmetrically integrates this prior into the sequence stream, preserving modality-specific modeling while enabling cross-modal enrichment. Built on a state space backbone, MuMo supports long-range dependency modeling and robust information propagation. Across 29 benchmark tasks from Therapeutics Data Commons (TDC) and MoleculeNet, MuMo achieves an average improvement of 2.7% over the best-performing baseline on each task, ranking first on 22 of them, including a 27% improvement on the LD50 task. These results validate its robustness to 3D conformer noise and the effectiveness of multimodal fusion in molecular representation. The code is available at: github.com/selmiss/MuMo.

Peptides are essential in biological processes and therapeutics. In this study, we introduce Multi-Peptide, an innovative approach that combines transformer-based language models with Graph Neural Networks (GNNs) to predict peptide properties. We combine PeptideBERT, a transformer model tailored for peptide property prediction, with a GNN encoder to capture both sequence-based and structural features. By employing Contrastive Language-Image Pre-training (CLIP), Multi-Peptide aligns embeddings from both modalities into a shared latent space, thereby enhancing the model's predictive accuracy. Evaluations on hemolysis and nonfouling datasets demonstrate Multi-Peptide's robustness, achieving state-of-the-art 86.185% accuracy in hemolysis prediction. This study highlights the potential of multimodal learning in bioinformatics, paving the way for accurate and reliable predictions in peptide-based research and applications.

Digital agents are increasingly employed to automate tasks in interactive digital environments such as web pages, software applications, and operating systems. While text-based agents built on Large Language Models (LLMs) often require frequent updates due to platform-specific APIs, visual agents leveraging Multimodal Large Language Models (MLLMs) offer enhanced adaptability by interacting directly with Graphical User Interfaces (GUIs). However, these agents face significant challenges in visual perception, particularly when handling high-resolution, visually complex digital environments. This paper introduces Iris, a foundational visual agent that addresses these challenges through two key innovations: Information-Sensitive Cropping (ISC) and Self-Refining Dual Learning (SRDL). ISC dynamically identifies and prioritizes visually dense regions using a edge detection algorithm, enabling efficient processing by allocating more computational resources to areas with higher information density. SRDL enhances the agent's ability to handle complex tasks by leveraging a dual-learning loop, where improvements in referring (describing UI elements) reinforce grounding (locating elements) and vice versa, all without requiring additional annotated data. Empirical evaluations demonstrate that Iris achieves state-of-the-art performance across multiple benchmarks with only 850K GUI annotations, outperforming methods using 10x more training data. These improvements further translate to significant gains in both web and OS agent downstream tasks.

We aim to develop a multimodal research agent capable of explicit reasoning and planning, multi-tool invocation, and cross-modal information synthesis, enabling it to conduct deep research tasks. However, we observe three main challenges in developing such agents: (1) scarcity of search-intensive multimodal QA data, (2) lack of effective search trajectories, and (3) prohibitive cost of training with online search APIs. To tackle them, we first propose Hyper-Search, a hypergraph-based QA generation method that models and connects visual and textual nodes within and across modalities, enabling to generate search-intensive multimodal QA pairs that require invoking various search tools to solve. Second, we introduce DR-TTS, which first decomposes search-involved tasks into several categories according to search tool types, and respectively optimize specialized search tool experts for each tool. It then recomposes tool experts to jointly explore search trajectories via tree search, producing trajectories that successfully solve complex tasks using various search tools. Third, we build an offline search engine supporting multiple search tools, enabling agentic reinforcement learning without using costly online search APIs. With the three designs, we develop MM-DeepResearch, a powerful multimodal deep research agent, and extensive results shows its superiority across benchmarks. Code is available at https://github.com/HJYao00/MM-DeepResearch

Multimodal agents, which integrate a controller e.g., a vision language model) with external tools, have demonstrated remarkable capabilities in tackling complex multimodal tasks. Existing approaches for training these agents, both supervised fine-tuning and reinforcement learning, depend on extensive human-annotated task-answer pairs and tool trajectories. However, for complex multimodal tasks, such annotations are prohibitively expensive or impractical to obtain. In this paper, we propose an iterative tool usage exploration method for multimodal agents without any pre-collected data, namely SPORT, via step-wise preference optimization to refine the trajectories of tool usage. Our method enables multimodal agents to autonomously discover effective tool usage strategies through self-exploration and optimization, eliminating the bottleneck of human annotation. SPORT has four iterative components: task synthesis, step sampling, step verification, and preference tuning. We first synthesize multimodal tasks using language models. Then, we introduce a novel trajectory exploration scheme, where step sampling and step verification are executed alternately to solve synthesized tasks. In step sampling, the agent tries different tools and obtains corresponding results. In step verification, we employ a verifier to provide AI feedback to construct step-wise preference data. The data is subsequently used to update the controller for tool usage through preference tuning, producing a SPORT agent. By interacting with real environments, the SPORT agent gradually evolves into a more refined and capable system. Evaluation in the GTA and GAIA benchmarks shows that the SPORT agent achieves 6.41% and 3.64% improvements, underscoring the generalization and effectiveness introduced by our method. The project page is https://SPORT-Agents.github.io.

The advent of multimodal agents facilitates effective interaction within graphical user interface (GUI), especially in ubiquitous GUI control. However, their inability to reliably execute toggle control instructions remains a key bottleneck. To investigate this, we construct a state control benchmark with binary toggle instructions from public datasets. Evaluations of existing agents demonstrate their unreliability, particularly when the current toggle state already matches the desired state. To address the challenge, we propose State-aware Reasoning (StaR), a training method that teaches agents to perceive the current toggle state, analyze the desired state from the instruction, and act accordingly. Experiments on three multimodal agents demonstrate that StaR can improve toggle instruction execution accuracy by over 30\%. Further evaluations on three public benchmarks show that StaR also enhances general task performance. Finally, evaluations on a dynamic environment highlight the potential of StaR for real-world applications. Code, benchmark, and StaR-enhanced agents are available at https://github.com/ZrW00/StaR.

Real-world multimodal agents solve multi-step workflows grounded in visual evidence. For example, an agent can troubleshoot a device by linking a wiring photo to a schematic and validating the fix with online documentation, or plan a trip by interpreting a transit map and checking schedules under routing constraints. However, existing multimodal benchmarks mainly evaluate single-turn visual reasoning or specific tool skills, and they do not fully capture the realism, visual subtlety, and long-horizon tool use that practical agents require. We introduce AgentVista, a benchmark for generalist multimodal agents that spans 25 sub-domains across 7 categories, pairing realistic and detail-rich visual scenarios with natural hybrid tool use. Tasks require long-horizon tool interactions across modalities, including web search, image search, page navigation, and code-based operations for both image processing and general programming. Comprehensive evaluation of state-of-the-art models exposes significant gaps in their ability to carry out long-horizon multimodal tool use. Even the best model in our evaluation, Gemini-3-Pro with tools, achieves only 27.3% overall accuracy, and hard instances can require more than 25 tool-calling turns. We expect AgentVista to accelerate the development of more capable and reliable multimodal agents for realistic and ultra-challenging problem solving.

Developing agents that can follow multimodal instructions remains a fundamental challenge in robotics and AI. Although large-scale pre-training on unlabeled datasets (no language instruction) has enabled agents to learn diverse behaviors, these agents often struggle with following instructions. While augmenting the dataset with instruction labels can mitigate this issue, acquiring such high-quality annotations at scale is impractical. To address this issue, we frame the problem as a semi-supervised learning task and introduce GROOT-2, a multimodal instructable agent trained using a novel approach that combines weak supervision with latent variable models. Our method consists of two key components: constrained self-imitating, which utilizes large amounts of unlabeled demonstrations to enable the policy to learn diverse behaviors, and human intention alignment, which uses a smaller set of labeled demonstrations to ensure the latent space reflects human intentions. GROOT-2's effectiveness is validated across four diverse environments, ranging from video games to robotic manipulation, demonstrating its robust multimodal instruction-following capabilities.

Vision language models (VLMs) are increasingly deployed as controllers with access to external tools for complex reasoning and decision-making, yet their effectiveness remains limited by the scarcity of high-quality multimodal trajectories and the cost of manual annotation. We address this challenge with a vision-centric agent tuning framework that automatically synthesizes multimodal trajectories, generates step-wise preference pairs, and trains a VLM controller for robust tool-use reasoning. Our pipeline first constructs M-TRACE, a large-scale dataset of 28.5K multimodal tasks with 177K verified trajectories, enabling imitation-based trajectory tuning. Building on this, we develop MATRIX Agent, a controller finetuned on M-TRACE for step-wise tool reasoning. To achieve finer alignment, we further introduce Pref-X, a set of 11K automatically generated preference pairs, and optimize MATRIX on it via step-wise preference learning. Across three benchmarks, Agent-X, GTA, and GAIA, MATRIX consistently surpasses both open- and closed-source VLMs, demonstrating scalable and effective multimodal tool use. Our data and code is avaliable at https://github.com/mbzuai-oryx/MATRIX.

Modern conversational agents like ChatGPT and Alexa+ rely on predefined policies specifying metadata, response styles, and tool-usage rules. As these LLM-based systems expand to support diverse business and user queries, such policies, often implemented as in-context prompts, are becoming increasingly complex and lengthy, making faithful adherence difficult and imposing large fixed computational costs. With the rise of multimodal agents, policies that govern visual and multimodal behaviors are critical but remain understudied. Prior prompt-compression work mainly shortens task templates and demonstrations, while existing policy-alignment studies focus only on text-based safety rules. We introduce Multimodal Policy Internalization (MPI), a new task that internalizes reasoning-intensive multimodal policies into model parameters, enabling stronger policy-following without including the policy during inference. MPI poses unique data and algorithmic challenges. We build two datasets spanning synthetic and real-world decision-making and tool-using tasks and propose TriMPI, a three-stage training framework. TriMPI first injects policy knowledge via continual pretraining, then performs supervised finetuning, and finally applies PolicyRollout, a GRPO-style reinforcement learning extension that augments rollouts with policy-aware responses for grounded exploration. TriMPI achieves notable gains in end-to-end accuracy, generalization, and robustness to forgetting. As the first work on multimodal policy internalization, we provide datasets, training recipes, and comprehensive evaluations to foster future research. Project page: https://mikewangwzhl.github.io/TriMPI.

Multimodal large language models (MLLMs) have demonstrated strong capabilities in visual understanding, yet they remain limited in complex, multi-step reasoning that requires deep searching and integrating visual evidence with external knowledge. In this work, we address this challenge by constructing high-quality, verified multi-hop vision-language training data for multimodal deep-search agents. We propose a Multi-hop Tool-Augmented Agent for Evidence-based QA Synthesis (MTA-Agent), which automatically selects tools and their parameters to retrieve and validate evidence from both visual and textual sources and generates structured multi-hop question-answer trajectories. Starting from diverse VQA seed datasets, our pipeline produces a large-scale training dataset, MTA-Vision-DeepSearch, containing 21K high-quality multi-hop examples. The data is filtered through a multi-stage verification process to ensure factual consistency and answer uniqueness. Using MTA-Vision-DeepSearch, a 32B open-source multimodal search agent achieves state-of-the-art performance, reaching an average of 54.63\% across six challenging benchmarks, outperforming GPT-5 (51.86\%), Gemini-2.5-Pro (50.98\%), and Gemini-3-Pro (54.46\%) under the same tool settings. We further show that training on our data improves both reasoning depth and tool-use behavior, increasing the average number of steps from 2.27 to 4.28, and leading to more systematic and persistent search strategies. Additionally, we demonstrate that training can be performed without real-time tool calls by replaying cached interactions, significantly reducing training cost. Importantly, we present MTA-Agent as a fully open recipe for multimodal deep search: we release the entire dataset, training trajectories, and implementation details to enable reproducibility and future research on open multimodal search agents.

Presentation generation is moving beyond static slide creation toward end-to-end presentation video generation with research grounding, multimodal media, and interactive delivery. We introduce PresentAgent-2, an agentic framework for generating presentation videos from user queries. Given an open-ended user query and a selected presentation mode, PresentAgent-2 first summarizes the query into a focused topic and performs deep research over presentation-friendly sources to collect multimodal resources, including relevant text, images, GIFs, and videos. It then constructs presentation slides, generates mode-specific scripts, and composes slides, audio, and dynamic media into a complete presentation video. PresentAgent-2 supports three independent presentation modes within a unified framework: Single Presentation, which generates a single-speaker narrated presentation video; Discussion, which creates a multi-speaker presentation with structured speaker roles, such as for asking guiding questions, explaining concepts, clarifying details, and summarizing key points; and Interaction, which independently supports answering audience questions grounded in the generated slides, scripts, retrieved evidence, and presentation context. To evaluate these capabilities, we build a multimodal presentation benchmark covering single presentation, discussion, and interaction scenarios, with task-specific evaluation criteria for content quality, media relevance, dynamic media use, dialogue naturalness, and interaction grounding. Overall, PresentAgent-2 extends presentation generation from document-dependent slide creation to query-driven, research-grounded presentation video generation with multimodal media, dialogue, and interaction. Code: https://github.com/AIGeeksGroup/PresentAgent-2. Website: https://aigeeksgroup.github.io/PresentAgent-2.

An elusive goal in navigation research is to build an intelligent agent that can understand multimodal instructions including natural language and image, and perform useful navigation. To achieve this, we study a widely useful category of navigation tasks we call Multimodal Instruction Navigation with demonstration Tours (MINT), in which the environment prior is provided through a previously recorded demonstration video. Recent advances in Vision Language Models (VLMs) have shown a promising path in achieving this goal as it demonstrates capabilities in perceiving and reasoning about multimodal inputs. However, VLMs are typically trained to predict textual output and it is an open research question about how to best utilize them in navigation. To solve MINT, we present Mobility VLA, a hierarchical Vision-Language-Action (VLA) navigation policy that combines the environment understanding and common sense reasoning power of long-context VLMs and a robust low-level navigation policy based on topological graphs. The high-level policy consists of a long-context VLM that takes the demonstration tour video and the multimodal user instruction as input to find the goal frame in the tour video. Next, a low-level policy uses the goal frame and an offline constructed topological graph to generate robot actions at every timestep. We evaluated Mobility VLA in a 836m^2 real world environment and show that Mobility VLA has a high end-to-end success rates on previously unsolved multimodal instructions such as "Where should I return this?" while holding a plastic bin.

The recent development on large multimodal models (LMMs), especially GPT-4V(ision) and Gemini, has been quickly expanding the capability boundaries of multimodal models beyond traditional tasks like image captioning and visual question answering. In this work, we explore the potential of LMMs like GPT-4V as a generalist web agent that can follow natural language instructions to complete tasks on any given website. We propose SEEACT, a generalist web agent that harnesses the power of LMMs for integrated visual understanding and acting on the web. We evaluate on the recent MIND2WEB benchmark. In addition to standard offline evaluation on cached websites, we enable a new online evaluation setting by developing a tool that allows running web agents on live websites. We show that GPT-4V presents a great potential for web agents - it can successfully complete 50% of the tasks on live websites if we manually ground its textual plans into actions on the websites. This substantially outperforms text-only LLMs like GPT-4 or smaller models (FLAN-T5 and BLIP-2) specifically fine-tuned for web agents. However, grounding still remains a major challenge. Existing LMM grounding strategies like set-of-mark prompting turns out not effective for web agents, and the best grounding strategy we develop in this paper leverages both the HTML text and visuals. Yet, there is still a substantial gap with oracle grounding, leaving ample room for further improvement.

Multi-Agent System (MAS) powered by Visual Language Models (VLMs) enables challenging tasks but suffers from a novel failure term, multi-agent visual hallucination snowballing, where hallucinations are seeded in a single agent and amplified by following ones due to the over-reliance on textual flow to relay visual information. Through turn-, layer-, and token-wise attention analyses, we provide detailed insights into the essence of hallucination snowballing regarding the reduction of visual attention allocation. It leads us to identify a subset of vision tokens with a unimodal attention peak in middle layers that best preserve visual evidence but gradually diminish in deeper agent turns, resulting in the visual hallucination snowballing in MAS. Thus, we propose ViF, a lightweight, plug-and-play mitigation paradigm that relays inter-agent messages with Visual Flow powered by the selected visual relay tokens and applies attention reallocation to amplify this pattern. The experiment results demonstrate that our method markedly reduces hallucination snowballing, consistently improving the performance across eight benchmarks based on four common MAS structures and ten base models. The source code will be available at: https://github.com/YU-deep/ViF.git.

Recent success in large multimodal models (LMMs) has sparked promising applications of agents capable of autonomously completing complex web tasks. While open-source LMM agents have made significant advances in offline evaluation benchmarks, their performance still falls substantially short of human-level capabilities in more realistic online settings. A key bottleneck is the lack of diverse and large-scale trajectory-level datasets across various domains, which are expensive to collect. In this paper, we address this challenge by developing a scalable recipe to synthesize the largest and most diverse trajectory-level dataset to date, containing over 94K successful multimodal web trajectories, spanning 49K unique URLs, 720K screenshots, and 33M web elements. In particular, we leverage extensive web exploration and refinement to obtain diverse task intents. The average cost is 28 cents per successful trajectory, making it affordable to a wide range of users in the community. Leveraging this dataset, we train Explorer, a multimodal web agent, and demonstrate strong performance on both offline and online web agent benchmarks such as Mind2Web-Live, Multimodal-Mind2Web, and MiniWob++. Additionally, our experiments highlight data scaling as a key driver for improving web agent capabilities. We hope this study makes state-of-the-art LMM-based agent research at a larger scale more accessible.

The rapid development of large language and multimodal models has sparked significant interest in using proprietary models, such as GPT-4o, to develop autonomous agents capable of handling real-world scenarios like web navigation. Although recent open-source efforts have tried to equip agents with the ability to explore environments and continuously improve over time, they are building text-only agents in synthetic environments where the reward signals are clearly defined. Such agents struggle to generalize to realistic settings that require multimodal perception abilities and lack ground-truth signals. In this paper, we introduce an open-source framework designed to facilitate the development of multimodal web agent that can autonomously conduct real-world exploration and improve itself. We first train the base model with imitation learning to gain the basic abilities. We then let the agent explore the open web and collect feedback on its trajectories. After that, it further improves its policy by learning from well-performing trajectories judged by another general-purpose model. This exploration-feedback-optimization cycle can continue for several iterations. Experimental results show that our web agent successfully improves itself after each iteration, demonstrating strong performance across multiple test sets.

Multimodal Large Language Models (MLLMs) are evolving from passive observers into active agents, solving problems through Visual Expansion (invoking visual tools) and Knowledge Expansion (open-web search). However, existing evaluations fall short: they lack flexible tool integration, test visual and search tools separately, and evaluate primarily by final answers. Consequently, they cannot verify if tools were actually invoked, applied correctly, or used efficiently. To address this, we introduce Agentic-MME, a process-verified benchmark for Multimodal Agentic Capabilities. It contains 418 real-world tasks across 6 domains and 3 difficulty levels to evaluate capability synergy, featuring over 2,000 stepwise checkpoints that average 10+ person-hours of manual annotation per task. Each task includes a unified evaluation framework supporting sandboxed code and APIs, alongside a human reference trajectory annotated with stepwise checkpoints along dual-axis: S-axis and V-axis. To enable true process-level verification, we audit fine-grained intermediate states rather than just final answers, and quantify efficiency via an overthinking metric relative to human trajectories. Experimental results show the best model, Gemini3-pro, achieves 56.3% overall accuracy, which falls significantly to 23.0% on Level-3 tasks, underscoring the difficulty of real-world multimodal agentic problem solving.

The advancement of large language models (LLMs) prompts the development of multi-modal agents, which are used as a controller to call external tools, providing a feasible way to solve practical tasks. In this paper, we propose a multi-modal agent tuning method that automatically generates multi-modal tool-usage data and tunes a vision-language model (VLM) as the controller for powerful tool-usage reasoning. To preserve the data quality, we prompt the GPT-4o mini model to generate queries, files, and trajectories, followed by query-file and trajectory verifiers. Based on the data synthesis pipeline, we collect the MM-Traj dataset that contains 20K tasks with trajectories of tool usage. Then, we develop the T3-Agent via Trajectory Tuning on VLMs for Tool usage using MM-Traj. Evaluations on the GTA and GAIA benchmarks show that the T3-Agent consistently achieves improvements on two popular VLMs: MiniCPM-V-8.5B and {Qwen2-VL-7B}, which outperforms untrained VLMs by 20%, showing the effectiveness of the proposed data synthesis pipeline, leading to high-quality data for tool-usage capabilities.

We explore how reconciling several foundation models (large language models and vision-language models) with a novel unified memory mechanism could tackle the challenging video understanding problem, especially capturing the long-term temporal relations in lengthy videos. In particular, the proposed multimodal agent VideoAgent: 1) constructs a structured memory to store both the generic temporal event descriptions and object-centric tracking states of the video; 2) given an input task query, it employs tools including video segment localization and object memory querying along with other visual foundation models to interactively solve the task, utilizing the zero-shot tool-use ability of LLMs. VideoAgent demonstrates impressive performances on several long-horizon video understanding benchmarks, an average increase of 6.6% on NExT-QA and 26.0% on EgoSchema over baselines, closing the gap between open-sourced models and private counterparts including Gemini 1.5 Pro.

We present PresentAgent, a multimodal agent that transforms long-form documents into narrated presentation videos. While existing approaches are limited to generating static slides or text summaries, our method advances beyond these limitations by producing fully synchronized visual and spoken content that closely mimics human-style presentations. To achieve this integration, PresentAgent employs a modular pipeline that systematically segments the input document, plans and renders slide-style visual frames, generates contextual spoken narration with large language models and Text-to-Speech models, and seamlessly composes the final video with precise audio-visual alignment. Given the complexity of evaluating such multimodal outputs, we introduce PresentEval, a unified assessment framework powered by Vision-Language Models that comprehensively scores videos across three critical dimensions: content fidelity, visual clarity, and audience comprehension through prompt-based evaluation. Our experimental validation on a curated dataset of 30 document-presentation pairs demonstrates that PresentAgent approaches human-level quality across all evaluation metrics. These results highlight the significant potential of controllable multimodal agents in transforming static textual materials into dynamic, effective, and accessible presentation formats. Code will be available at https://github.com/AIGeeksGroup/PresentAgent.

Automating the generation of scientific videos is a crucial yet challenging task for effective knowledge dissemination. However, existing works on document automation primarily focus on static media such as posters and slides, lacking mechanisms for personalized dynamic orchestration and multimodal content synchronization. To address these challenges, we introduce VideoAgent, a novel multi-agent framework that synthesizes personalized scientific videos through a conversational interface. VideoAgent parses a source paper into a fine-grained asset library and, guided by user requirements, orchestrates a narrative flow that synthesizes both static slides and dynamic animations to explain complex concepts. To enable rigorous evaluation, we also propose SciVidEval, the first comprehensive suite for this task, which combines automated metrics for multimodal content quality and synchronization with a Video-Quiz-based human evaluation to measure knowledge transfer. Extensive experiments demonstrate that our method significantly outperforms existing commercial scientific video generation services and approaches human-level quality in scientific communication.

Recent advancements in multimodal large language models and vision-languageaction models have significantly driven progress in Embodied AI. As the field transitions toward more complex task scenarios, multi-agent system frameworks are becoming essential for achieving scalable, efficient, and collaborative solutions. This shift is fueled by three primary factors: increasing agent capabilities, enhancing system efficiency through task delegation, and enabling advanced human-agent interactions. To address the challenges posed by multi-agent collaboration, we propose the Multi-Agent Robotic System (MARS) Challenge, held at the NeurIPS 2025 Workshop on SpaVLE. The competition focuses on two critical areas: planning and control, where participants explore multi-agent embodied planning using vision-language models (VLMs) to coordinate tasks and policy execution to perform robotic manipulation in dynamic environments. By evaluating solutions submitted by participants, the challenge provides valuable insights into the design and coordination of embodied multi-agent systems, contributing to the future development of advanced collaborative AI systems.

Vision-enabled language models (VLMs) are now used to build autonomous multimodal agents capable of taking actions in real environments. In this paper, we show that multimodal agents raise new safety risks, even though attacking agents is more challenging than prior attacks due to limited access to and knowledge about the environment. Our attacks use adversarial text strings to guide gradient-based perturbation over one trigger image in the environment: (1) our captioner attack attacks white-box captioners if they are used to process images into captions as additional inputs to the VLM; (2) our CLIP attack attacks a set of CLIP models jointly, which can transfer to proprietary VLMs. To evaluate the attacks, we curated VisualWebArena-Adv, a set of adversarial tasks based on VisualWebArena, an environment for web-based multimodal agent tasks. Within an L-infinity norm of 16/256 on a single image, the captioner attack can make a captioner-augmented GPT-4V agent execute the adversarial goals with a 75% success rate. When we remove the captioner or use GPT-4V to generate its own captions, the CLIP attack can achieve success rates of 21% and 43%, respectively. Experiments on agents based on other VLMs, such as Gemini-1.5, Claude-3, and GPT-4o, show interesting differences in their robustness. Further analysis reveals several key factors contributing to the attack's success, and we also discuss the implications for defenses as well. Project page: https://chenwu.io/attack-agent Code and data: https://github.com/ChenWu98/agent-attack

This paper introduces InfantAgent-Next, a generalist agent capable of interacting with computers in a multimodal manner, encompassing text, images, audio, and video. Unlike existing approaches that either build intricate workflows around a single large model or only provide workflow modularity, our agent integrates tool-based and pure vision agents within a highly modular architecture, enabling different models to collaboratively solve decoupled tasks in a step-by-step manner. Our generality is demonstrated by our ability to evaluate not only pure vision-based real-world benchmarks (i.e., OSWorld), but also more general or tool-intensive benchmarks (e.g., GAIA and SWE-Bench). Specifically, we achieve 7.27% accuracy on OSWorld, higher than Claude-Computer-Use. Codes and evaluation scripts are open-sourced at https://github.com/bin123apple/InfantAgent.

Humans use different modalities, such as speech, text, images, videos, etc., to communicate their intent and goals with teammates. For robots to become better assistants, we aim to endow them with the ability to follow instructions and understand tasks specified by their human partners. Most robotic policy learning methods have focused on one single modality of task specification while ignoring the rich cross-modal information. We present MUTEX, a unified approach to policy learning from multimodal task specifications. It trains a transformer-based architecture to facilitate cross-modal reasoning, combining masked modeling and cross-modal matching objectives in a two-stage training procedure. After training, MUTEX can follow a task specification in any of the six learned modalities (video demonstrations, goal images, text goal descriptions, text instructions, speech goal descriptions, and speech instructions) or a combination of them. We systematically evaluate the benefits of MUTEX in a newly designed dataset with 100 tasks in simulation and 50 tasks in the real world, annotated with multiple instances of task specifications in different modalities, and observe improved performance over methods trained specifically for any single modality. More information at https://ut-austin-rpl.github.io/MUTEX/

The development of autonomous agents increasingly relies on Multimodal Language Models (MLMs) to perform tasks described in natural language with GUI environments, such as websites, desktop computers, or mobile phones. Existing benchmarks for MLM agents in interactive environments are limited by their focus on a single environment, lack of detailed and generalized evaluation methods, and the complexities of constructing tasks and evaluators. To overcome these limitations, we introduce Crab, the first agent benchmark framework designed to support cross-environment tasks, incorporating a graph-based fine-grained evaluation method and an efficient mechanism for task and evaluator construction. Our framework supports multiple devices and can be easily extended to any environment with a Python interface. Leveraging Crab, we developed a cross-platform Crab Benchmark-v0 comprising 100 tasks in computer desktop and mobile phone environments. We evaluated four advanced MLMs using different single and multi-agent system configurations on this benchmark. The experimental results demonstrate that the single agent with GPT-4o achieves the best completion ratio of 35.26%. All framework code, agent code, and task datasets are publicly available at https://github.com/camel-ai/crab.

Multimodal Large Language Models (MLLMs) have shown impressive reasoning abilities and general intelligence in various domains. It inspires researchers to train end-to-end MLLMs or utilize large models to generate policies with human-selected prompts for embodied agents. However, these methods exhibit limited generalization capabilities on unseen tasks or scenarios, and overlook the multimodal environment information which is critical for robots to make decisions. In this paper, we introduce a novel Robotic Multimodal Perception-Planning (RoboMP^2) framework for robotic manipulation which consists of a Goal-Conditioned Multimodal Preceptor (GCMP) and a Retrieval-Augmented Multimodal Planner (RAMP). Specially, GCMP captures environment states by employing a tailored MLLMs for embodied agents with the abilities of semantic reasoning and localization. RAMP utilizes coarse-to-fine retrieval method to find the k most-relevant policies as in-context demonstrations to enhance the planner. Extensive experiments demonstrate the superiority of RoboMP^2 on both VIMA benchmark and real-world tasks, with around 10% improvement over the baselines.

Multimodal agents are making rapid progress on general computer-use tasks, yet existing benchmarks remain largely confined to browsers and basic desktop applications, falling short in professional software workflows that dominate real-world scientific and industrial practice. To close this gap, we introduce ProSoftArena, a benchmark and platform specifically for evaluating multimodal agents in professional software environments. We establish the first capability hierarchy tailored to agent use of professional software and construct a benchmark of 436 realistic work and research tasks spanning 6 disciplines and 13 core professional applications. To ensure reliable and reproducible assessment, we build an executable real-computer environment with an execution-based evaluation framework and uniquely incorporate a human-in-the-loop evaluation paradigm. Extensive experiments show that even the best-performing agent attains only a 24.4\% success rate on L2 tasks and completely fails on L3 multi-software workflow. In-depth analysis further provides valuable insights for addressing current agent limitations and more effective design principles, paving the way to build more capable agents in professional software settings. This project is available at: https://prosoftarena.github.io.

Large language models (LLMs) and vision-language models (VLMs) have the potential to transform biological research by enabling autonomous experimentation. Yet, their application remains constrained by rigid protocol design, limited adaptability to dynamic lab conditions, inadequate error handling, and high operational complexity. Here we introduce BioMARS (Biological Multi-Agent Robotic System), an intelligent platform that integrates LLMs, VLMs, and modular robotics to autonomously design, plan, and execute biological experiments. BioMARS uses a hierarchical architecture: the Biologist Agent synthesizes protocols via retrieval-augmented generation; the Technician Agent translates them into executable robotic pseudo-code; and the Inspector Agent ensures procedural integrity through multimodal perception and anomaly detection. The system autonomously conducts cell passaging and culture tasks, matching or exceeding manual performance in viability, consistency, and morphological integrity. It also supports context-aware optimization, outperforming conventional strategies in differentiating retinal pigment epithelial cells. A web interface enables real-time human-AI collaboration, while a modular backend allows scalable integration with laboratory hardware. These results highlight the feasibility of generalizable, AI-driven laboratory automation and the transformative role of language-based reasoning in biological research.

Large Language Models (LLMs) and multi-agent systems have shown impressive capabilities in natural language tasks but face challenges in clinical trial applications, primarily due to limited access to external knowledge. Recognizing the potential of advanced clinical trial tools that aggregate and predict based on the latest medical data, we propose an integrated solution to enhance their accessibility and utility. We introduce Clinical Agent System (ClinicalAgent), a clinical multi-agent system designed for clinical trial tasks, leveraging GPT-4, multi-agent architectures, LEAST-TO-MOST, and ReAct reasoning technology. This integration not only boosts LLM performance in clinical contexts but also introduces novel functionalities. The proposed method achieves competitive predictive performance in clinical trial outcome prediction (0.7908 PR-AUC), obtaining a 0.3326 improvement over the standard prompt Method. Publicly available code can be found at https://anonymous.4open.science/r/ClinicalAgent-6671.

State-of-the-art multimodal web agents, powered by Multimodal Large Language Models (MLLMs), can autonomously execute many web tasks by processing user instructions and interacting with graphical user interfaces (GUIs). Current strategies for building web agents rely on (i) the generalizability of underlying MLLMs and their steerability via prompting, and (ii) large-scale fine-tuning of MLLMs on web-related tasks. However, web agents still struggle to automate tasks on unseen websites and domains, limiting their applicability to enterprise-specific and proprietary platforms. Beyond generalization from large-scale pre-training and fine-tuning, we propose building agents for few-shot adaptability using human demonstrations. We introduce the AdaptAgent framework that enables both proprietary and open-weights multimodal web agents to adapt to new websites and domains using few human demonstrations (up to 2). Our experiments on two popular benchmarks -- Mind2Web & VisualWebArena -- show that using in-context demonstrations (for proprietary models) or meta-adaptation demonstrations (for meta-learned open-weights models) boosts task success rate by 3.36% to 7.21% over non-adapted state-of-the-art models, corresponding to a relative increase of 21.03% to 65.75%. Furthermore, our additional analyses (a) show the effectiveness of multimodal demonstrations over text-only ones, (b) shed light on the influence of different data selection strategies during meta-learning on the generalization of the agent, and (c) demonstrate the effect of number of few-shot examples on the web agent's success rate. Overall, our results unlock a complementary axis for developing widely applicable multimodal web agents beyond large-scale pre-training and fine-tuning, emphasizing few-shot adaptability.

The advanced processing and reasoning capabilities of multimodal large language models (MLLMs) have driven substantial progress in vision-language (VL) understanding tasks. However, while effective for tasks governed by straightforward logic, MLLMs often encounter challenges when reasoning over complex, interdependent logic structures. To address this limitation, we introduce AgentPS, a novel framework that integrates Agentic Process Supervision into MLLMs via multi-round question answering during fine-tuning. AgentPS demonstrates significant performance improvements over baseline MLLMs on proprietary TikTok datasets, due to its integration of process supervision and structured sequential reasoning. Furthermore, we show that replacing human-annotated labels with LLM-generated labels retains much of the performance gain, highlighting the framework's practical scalability in industrial applications. These results position AgentPS as a highly effective and efficient architecture for multimodal classification tasks. Its adaptability and scalability, especially when enhanced by automated annotation generation, make it a powerful tool for handling large-scale, real-world challenges.

Reliable forecasting of the future behavior of road agents is a critical component to safe planning in autonomous vehicles. Here, we represent continuous trajectories as sequences of discrete motion tokens and cast multi-agent motion prediction as a language modeling task over this domain. Our model, MotionLM, provides several advantages: First, it does not require anchors or explicit latent variable optimization to learn multimodal distributions. Instead, we leverage a single standard language modeling objective, maximizing the average log probability over sequence tokens. Second, our approach bypasses post-hoc interaction heuristics where individual agent trajectory generation is conducted prior to interactive scoring. Instead, MotionLM produces joint distributions over interactive agent futures in a single autoregressive decoding process. In addition, the model's sequential factorization enables temporally causal conditional rollouts. The proposed approach establishes new state-of-the-art performance for multi-agent motion prediction on the Waymo Open Motion Dataset, ranking 1st on the interactive challenge leaderboard.

Recent advancements in Vision Language Models (VLMs) have expanded their capabilities to interactive agent tasks, yet existing benchmarks remain limited to single-agent or text-only environments. In contrast, real-world scenarios often involve multiple agents interacting within rich visual and linguistic contexts, posing challenges with both multimodal observations and strategic interactions. To bridge this gap, we introduce Visual Strategic Bench (VS-Bench), a multimodal benchmark that evaluates VLMs for strategic reasoning and decision-making in multi-agent environments. VS-Bench comprises eight vision-grounded environments spanning cooperative, competitive, and mixed-motive interactions, designed to assess agents' ability to predict others' future moves and optimize for long-term objectives. We consider two complementary evaluation dimensions, including offline evaluation of strategic reasoning by next-action prediction accuracy and online evaluation of decision-making by normalized episode return. Extensive experiments of fourteen leading VLMs reveal a significant gap between current models and optimal performance, with the best models attaining 47.8% prediction accuracy and 24.3% normalized return. We further conduct in-depth analyses on multimodal observations, test-time scaling, social behaviors, and failure cases of VLM agents. By standardizing the evaluation and highlighting the limitations of existing models, we envision VS-Bench as a foundation for future research on strategic multimodal agents. Code and data are available at https://vs-bench.github.io.

Web agents--autonomous systems that navigate and execute tasks on the web on behalf of users--have the potential to transform how people interact with the digital world. However, the most capable web agents today rely on proprietary models with undisclosed training data and recipes, limiting scientific understanding, reproducibility, and community-driven progress. We believe agents for the open web should be built in the open. To this end, we introduce (1) MolmoWebMix, a large and diverse mixture of browser task demonstrations and web-GUI perception data and (2) MolmoWeb, a family of fully open multimodal web agents. Specifically, MolmoWebMix combines over 100K synthetic task trajectories from multiple complementary generation pipelines with 30K+ human demonstrations, atomic web-skill trajectories, and GUI perception data, including referring expression grounding and screenshot question answering. MolmoWeb agents operate as instruction-conditioned visual-language action policies: given a task instruction and a webpage screenshot, they predict the next browser action, requiring no access to HTML, accessibility trees, or specialized APIs. Available in 4B and 8B size, on browser-use benchmarks like WebVoyager, Online-Mind2Web, and DeepShop, MolmoWeb agents achieve state-of-the-art results outperforming similar scale open-weight-only models such as Fara-7B, UI-Tars-1.5-7B, and Holo1-7B. MolmoWeb-8B also surpasses set-of-marks (SoM) agents built on much larger closed frontier models like GPT-4o. We further demonstrate consistent gains through test-time scaling via parallel rollouts with best-of-N selection, achieving 94.7% and 60.5% pass@4 (compared to 78.2% and 35.3% pass@1) on WebVoyager and Online-Mind2Web respectively. We will release model checkpoints, training data, code, and a unified evaluation harness to enable reproducibility and accelerate open research on web agents.

Large multimodal language models (MLLMs) are increasingly deployed as web agents, yet many multimodal browsing benchmarks can be solved by shallow, fixed workflows that lean on high-recall image search and nearby text-masking the genuinely multimodal challenges of fine-grained visual reasoning, provenance verification, and long-horizon tool use. We introduce MMSearch-Plus, a benchmark of 311 tasks that highly demand multimodal understanding while preserving the difficulty profile of strong text-only browsing suites. Each item is constructed to contain multiple weak, localized visual signals that must be extracted, propagated through iterative text-image search, and cross-validated under retrieval noise before answering. Our curation procedure, Spatial-Temporal Extrapolation, seeds questions whose answers require extrapolating from spatial cues (micro-text, part-level appearance, layouts, signage) and temporal traces (broadcast overlays, seasonal context) to out-of-image facts such as events, dates, and venues. We provide a model-agnostic agent framework with browsing tools and evaluate a range of closed and open MLLMs. The strongest agent (o3) attains 15.1% without search and 36.0% accuracy with rollout under our framework, while a strong open-source model (Qwen-2.5-VL-72B-Instruct) achieves 0.0% without search and 6.9% after 20 rounds of search. Beyond answer accuracy, we assess bounding-box production and cropped-image search, and conduct an error analysis that surfaces failures in source verification, part-based reasoning, and long-horizon planning.

The development of artificial intelligence systems is transitioning from creating static, task-specific models to dynamic, agent-based systems capable of performing well in a wide range of applications. We propose an Interactive Agent Foundation Model that uses a novel multi-task agent training paradigm for training AI agents across a wide range of domains, datasets, and tasks. Our training paradigm unifies diverse pre-training strategies, including visual masked auto-encoders, language modeling, and next-action prediction, enabling a versatile and adaptable AI framework. We demonstrate the performance of our framework across three separate domains -- Robotics, Gaming AI, and Healthcare. Our model demonstrates its ability to generate meaningful and contextually relevant outputs in each area. The strength of our approach lies in its generality, leveraging a variety of data sources such as robotics sequences, gameplay data, large-scale video datasets, and textual information for effective multimodal and multi-task learning. Our approach provides a promising avenue for developing generalist, action-taking, multimodal systems.

Most medical multimodal benchmarks focus on static tasks such as image question answering, report generation, and plain-language rewriting. Patient education is more demanding: systems must identify relevant evidence across images, show patients where to look, explain findings in accessible language, and handle confusion or distress. Yet most patient education work remains text-only, even though combined image-and-text explanations may better support understanding. We introduce MedImageEdu, a benchmark for multi-turn, evidence-grounded radiology patient education. Each case provides a radiology report with report text and case images. A DoctorAgent interacts with a PatientAgent, conditioned on a hidden profile that captures factors such as education level, health literacy, and personality. When a patient question would benefit from visual support, the DoctorAgent can issue drawing instructions grounded in the report, case images, and the current question to a benchmark-provided drawing tool. The tool returns image(s), after which the DoctorAgent produces a final multimodal response consisting of the image(s) and a grounded plain-language explanation. MedImageEdu contains 150 cases from three sources and evaluates both the consultation process and the final multimodal response along five dimensions: Consultation, Safety and Scope, Language Quality, Drawing Quality, and Image-Text Response Quality. Across representative open- and closed-source vision-language model agents, we find three consistent gaps: fluent language often outpaces faithful visual grounding, safety is the weakest dimension across disease categories, and emotionally tense interactions are harder than low education or low health literacy. MedImageEdu provides a controlled testbed for assessing whether multimodal agents can teach from evidence rather than merely answer from text.

Accessibility remains a critical concern in today's society, as many technologies are not developed to support the full range of user needs. Existing multi-agent systems (MAS) often cannot provide comprehensive assistance for users in need due to the lack of customization stemming from closed-source designs. Consequently, individuals with disabilities frequently encounter significant barriers when attempting to interact with digital environments. We introduce MATE, a multimodal accessibility MAS, which performs the modality conversions based on the user's needs. The system is useful for assisting people with disabilities by ensuring that data will be converted to an understandable format. For instance, if the user cannot see well and receives an image, the system converts this image to its audio description. MATE can be applied to a wide range of domains, industries, and areas, such as healthcare, and can become a useful assistant for various groups of users. The system supports multiple types of models, ranging from LLM API calling to using custom machine learning (ML) classifiers. This flexibility ensures that the system can be adapted to various needs and is compatible with a wide variety of hardware. Since the system is expected to run locally, it ensures the privacy and security of sensitive information. In addition, the framework can be effectively integrated with institutional technologies (e.g., digital healthcare service) for real-time user assistance. Furthermore, we introduce ModCon-Task-Identifier, a model that is capable of extracting the precise modality conversion task from the user input. Numerous experiments show that ModCon-Task-Identifier consistently outperforms other LLMs and statistical models on our custom data. Our code and data are publicly available at https://github.com/AlgazinovAleksandr/Multi-Agent-MATE.

REST APIs play important roles in enriching the action space of web agents, yet most API-based agents rely on curated and uniform toolsets that do not reflect the complexity of real-world APIs. Building tool-using agents for arbitrary domains remains a major challenge, as it requires reading unstructured API documentation, testing APIs and inferring correct parameters. We propose Doc2Agent, a scalable pipeline to build agents that can call Python-based tools generated from API documentation. Doc2Agent generates executable tools from API documentations and iteratively refines them using a code agent. We evaluate our approach on real-world APIs, WebArena APIs, and research APIs, producing validated tools. We achieved a 55\% relative performance improvement with 90\% lower cost compared to direct API calling on WebArena benchmark. A domain-specific agent built for glycomaterial science further demonstrates the pipeline's adaptability to complex, knowledge-rich tasks. Doc2Agent offers a generalizable solution for building tool agents from unstructured API documentation at scale.

The complex nature of big biological systems pushed some scientists to classify its understanding under the inconceivable missions. Different leveled challenges complicated this task, one of is the prediction of a protein's function. In recent years, significant progress has been made in this field through the development of various machine learning approaches. However, most existing methods formulate the task as a multi-classification problem, i.e assigning predefined labels to proteins. In this work, we propose a novel approach, Prot2Text, which predicts a protein function's in a free text style, moving beyond the conventional binary or categorical classifications. By combining Graph Neural Networks(GNNs) and Large Language Models(LLMs), in an encoder-decoder framework, our model effectively integrates diverse data types including proteins' sequences, structures, and textual annotations. This multimodal approach allows for a holistic representation of proteins' functions, enabling the generation of detailed and accurate descriptions. To evaluate our model, we extracted a multimodal protein dataset from SwissProt, and demonstrate empirically the effectiveness of Prot2Text. These results highlight the transformative impact of multimodal models, specifically the fusion of GNNs and LLMs, empowering researchers with powerful tools for more accurate prediction of proteins' functions. The code, the models and a demo will be publicly released.

Mobile agents are essential for automating tasks in complex and dynamic mobile environments. As foundation models evolve, the demands for agents that can adapt in real-time and process multimodal data have grown. This survey provides a comprehensive review of mobile agent technologies, focusing on recent advancements that enhance real-time adaptability and multimodal interaction. Recent evaluation benchmarks have been developed better to capture the static and interactive environments of mobile tasks, offering more accurate assessments of agents' performance. We then categorize these advancements into two main approaches: prompt-based methods, which utilize large language models (LLMs) for instruction-based task execution, and training-based methods, which fine-tune multimodal models for mobile-specific applications. Additionally, we explore complementary technologies that augment agent performance. By discussing key challenges and outlining future research directions, this survey offers valuable insights for advancing mobile agent technologies. A comprehensive resource list is available at https://github.com/aialt/awesome-mobile-agents

This paper investigates the faithfulness of multimodal large language model (MLLM) agents in the graphical user interface (GUI) environment, aiming to address the research question of whether multimodal GUI agents can be distracted by environmental context. A general setting is proposed where both the user and the agent are benign, and the environment, while not malicious, contains unrelated content. A wide range of MLLMs are evaluated as GUI agents using our simulated dataset, following three working patterns with different levels of perception. Experimental results reveal that even the most powerful models, whether generalist agents or specialist GUI agents, are susceptible to distractions. While recent studies predominantly focus on the helpfulness (i.e., action accuracy) of multimodal agents, our findings indicate that these agents are prone to environmental distractions, resulting in unfaithful behaviors. Furthermore, we switch to the adversarial perspective and implement environment injection, demonstrating that such unfaithfulness can be exploited, leading to unexpected risks.

Multi-modal AI systems will likely become a ubiquitous presence in our everyday lives. A promising approach to making these systems more interactive is to embody them as agents within physical and virtual environments. At present, systems leverage existing foundation models as the basic building blocks for the creation of embodied agents. Embedding agents within such environments facilitates the ability of models to process and interpret visual and contextual data, which is critical for the creation of more sophisticated and context-aware AI systems. For example, a system that can perceive user actions, human behavior, environmental objects, audio expressions, and the collective sentiment of a scene can be used to inform and direct agent responses within the given environment. To accelerate research on agent-based multimodal intelligence, we define "Agent AI" as a class of interactive systems that can perceive visual stimuli, language inputs, and other environmentally-grounded data, and can produce meaningful embodied action with infinite agent. In particular, we explore systems that aim to improve agents based on next-embodied action prediction by incorporating external knowledge, multi-sensory inputs, and human feedback. We argue that by developing agentic AI systems in grounded environments, one can also mitigate the hallucinations of large foundation models and their tendency to generate environmentally incorrect outputs. The emerging field of Agent AI subsumes the broader embodied and agentic aspects of multimodal interactions. Beyond agents acting and interacting in the physical world, we envision a future where people can easily create any virtual reality or simulated scene and interact with agents embodied within the virtual environment.

Drug discovery typically consists of multiple steps, including identifying a target protein key to a disease's etiology, validating that interacting with this target could prevent symptoms or cure the disease, discovering a small molecule or biologic therapeutic to interact with it, and optimizing the candidate molecule through a complex landscape of required properties. Drug discovery related tasks often involve prediction and generation while considering multiple entities that potentially interact, which poses a challenge for typical AI models. For this purpose we present MAMMAL - Molecular Aligned Multi-Modal Architecture and Language - a method that we applied to create a versatile multi-task foundation model ibm/biomed.omics.bl.sm.ma-ted-458m that learns from large-scale biological datasets (2 billion samples) across diverse modalities, including proteins, small molecules, and genes. We introduce a prompt syntax that supports a wide range of classification, regression, and generation tasks. It allows combining different modalities and entity types as inputs and/or outputs. Our model handles combinations of tokens and scalars and enables the generation of small molecules and proteins, property prediction, and transcriptomic lab test predictions. We evaluated the model on 11 diverse downstream tasks spanning different steps within a typical drug discovery pipeline, where it reaches new SOTA in 9 tasks and is comparable to SOTA in 2 tasks. This performance is achieved while using a unified architecture serving all tasks, in contrast to the original SOTA performance achieved using tailored architectures. The model code and pretrained weights are publicly available at https://github.com/BiomedSciAI/biomed-multi-alignment and https://huggingface.co/ibm/biomed.omics.bl.sm.ma-ted-458m.

Multimodal large language models (MLLMs) have made impressive progress in many applications in recent years. However, chemical MLLMs that can handle cross-modal understanding and generation remain underexplored. To fill this gap, in this paper, we propose ChemMLLM, a unified chemical multimodal large language model for molecule understanding and generation. Also, we design five multimodal tasks across text, molecular SMILES strings, and image, and curate the datasets. We benchmark ChemMLLM against a range of general leading MLLMs and Chemical LLMs on these tasks. Experimental results show that ChemMLLM achieves superior performance across all evaluated tasks. For example, in molecule image optimization task, ChemMLLM outperforms the best baseline (GPT-4o) by 118.9\% (4.27 vs 1.95 property improvement). The code is publicly available at https://github.com/bbsbz/ChemMLLM.git.

Prompt-based learning has emerged as a successful paradigm in natural language processing, where a single general-purpose language model can be instructed to perform any task specified by input prompts. Yet task specification in robotics comes in various forms, such as imitating one-shot demonstrations, following language instructions, and reaching visual goals. They are often considered different tasks and tackled by specialized models. This work shows that we can express a wide spectrum of robot manipulation tasks with multimodal prompts, interleaving textual and visual tokens. We design a transformer-based generalist robot agent, VIMA, that processes these prompts and outputs motor actions autoregressively. To train and evaluate VIMA, we develop a new simulation benchmark with thousands of procedurally-generated tabletop tasks with multimodal prompts, 600K+ expert trajectories for imitation learning, and four levels of evaluation protocol for systematic generalization. VIMA achieves strong scalability in both model capacity and data size. It outperforms prior SOTA methods in the hardest zero-shot generalization setting by up to 2.9times task success rate given the same training data. With 10times less training data, VIMA still performs 2.7times better than the top competing approach. We open-source all code, pretrained models, dataset, and simulation benchmark at https://vimalabs.github.io

Multimodal large language models (MLLMs) have made significant progress in mobile agent development, yet their capabilities are predominantly confined to a reactive paradigm, where they merely execute explicit user commands. The emerging paradigm of proactive intelligence, where agents autonomously anticipate needs and initiate actions, represents the next frontier for mobile agents. However, its development is critically bottlenecked by the lack of benchmarks that can address real-world complexity and enable objective, executable evaluation. To overcome these challenges, we introduce ProactiveMobile, a comprehensive benchmark designed to systematically advance research in this domain. ProactiveMobile formalizes the proactive task as inferring latent user intent across four dimensions of on-device contextual signals and generating an executable function sequence from a comprehensive function pool of 63 APIs. The benchmark features over 3,660 instances of 14 scenarios that embrace real-world complexity through multi-answer annotations. To ensure quality, a team of 30 experts conducts a final audit of the benchmark, verifying factual accuracy, logical consistency, and action feasibility, and correcting any non-compliant entries. Extensive experiments demonstrate that our fine-tuned Qwen2.5-VL-7B-Instruct achieves a success rate of 19.15%, outperforming o1 (15.71%) and GPT-5 (7.39%). This result indicates that proactivity is a critical competency widely lacking in current MLLMs, yet it is learnable, emphasizing the importance of the proposed benchmark for proactivity evaluation.

Rationality is the quality of being guided by reason, characterized by decision-making that aligns with evidence and logical principles. It plays a crucial role in reliable problem-solving by ensuring well-grounded and consistent solutions. While large language models (LLMs) have made significant progress in generating human-like text, they still exhibit limitations such as bounded knowledge space and inconsistent outputs. In response, recent efforts have shifted toward developing multimodal and multi-agent systems, as well as integrating modules like external tools, programming codes, symbolic reasoners, utility function, and conformal risk controls rather than relying solely on a single LLM for decision-making. This paper surveys the state-of-the-art advancements in language and multimodal agents, evaluates how they contribute to make intelligent agents more rational, and identifies open challenges and future research directions. We maintain an open repository at https://github.com/bowen-upenn/Agent_Rationality.

Recently, image-based Large Multimodal Models (LMMs) have made significant progress in video question-answering (VideoQA) using a frame-wise approach by leveraging large-scale pretraining in a zero-shot manner. Nevertheless, these models need to be capable of finding relevant information, extracting it, and answering the question simultaneously. Currently, existing methods perform all of these steps in a single pass without being able to adapt if insufficient or incorrect information is collected. To overcome this, we introduce a modular multi-LMM agent framework based on several agents with different roles, instructed by a Planner agent that updates its instructions using shared feedback from the other agents. Specifically, we propose TraveLER, a method that can create a plan to "Traverse" through the video, ask questions about individual frames to "Locate" and store key information, and then "Evaluate" if there is enough information to answer the question. Finally, if there is not enough information, our method is able to "Replan" based on its collected knowledge. Through extensive experiments, we find that the proposed TraveLER approach improves performance on several VideoQA benchmarks without the need to fine-tune on specific datasets. Our code is available at https://github.com/traveler-framework/TraveLER.

Multimodal Large Language Models (MLLMs) have achieved remarkable progress in vision-language tasks yet remain limited in long video understanding due to the limited context window. Consequently, prevailing approaches tend to rely on uniform frame sampling or static pre-selection, which might overlook critical evidence and unable to correct its initial selection error during its reasoning process. To overcome these limitations, we propose VideoZoomer, a novel agentic framework that enables MLLMs to dynamically control their visual focus during reasoning. Starting from a coarse low-frame-rate overview, VideoZoomer invokes a temporal zoom tool to obtain high-frame-rate clips at autonomously chosen moments, thereby progressively gathering fine-grained evidence in a multi-turn interactive manner. Accordingly, we adopt a two-stage training strategy: a cold-start supervised fine-tuning phase on a curated dataset of distilled exemplar and reflection trajectories, followed by reinforcement learning to further refine the agentic policy. Extensive experiments demonstrate that our 7B model delivers diverse and complex reasoning patterns, yielding strong performance across a broad set of long video understanding and reasoning benchmarks. These emergent capabilities allow it to consistently surpass existing open-source models and even rival proprietary systems on challenging tasks, while achieving superior efficiency under reduced frame budgets.

Modern Artificial Intelligence (AI) increasingly relies on multi-agent architectures that blend visual and language understanding. Yet, a pressing challenge remains: How can we trust these agents especially in zero-shot settings with no fine-tuning? We introduce a novel modular Agentic AI visual classification framework that integrates generalist multimodal agents with a non-visual reasoning orchestrator and a Retrieval-Augmented Generation (RAG) module. Applied to apple leaf disease diagnosis, we benchmark three configurations: (I) zero-shot with confidence-based orchestration, (II) fine-tuned agents with improved performance, and (III) trust-calibrated orchestration enhanced by CLIP-based image retrieval and re-evaluation loops. Using confidence calibration metrics (ECE, OCR, CCC), the orchestrator modulates trust across agents. Our results demonstrate a 77.94\% accuracy improvement in the zero-shot setting using trust-aware orchestration and RAG, achieving 85.63\% overall. GPT-4o showed better calibration, while Qwen-2.5-VL displayed overconfidence. Furthermore, image-RAG grounded predictions with visually similar cases, enabling correction of agent overconfidence via iterative re-evaluation. The proposed system separates perception (vision agents) from meta-reasoning (orchestrator), enabling scalable and interpretable multi-agent AI. This blueprint is extensible to diagnostics, biology, and other trust-critical domains. All models, prompts, results, and system components including the complete software source code are openly released to support reproducibility, transparency, and community benchmarking at Github: https://github.com/Applied-AI-Research-Lab/Orchestrator-Agent-Trust

Medical image segmentation is fundamental for biomedical discovery. Existing methods lack generalizability and demand extensive, time-consuming manual annotation for new clinical application. Here, we propose MedSAM-3, a text promptable medical segmentation model for medical image and video segmentation. By fine-tuning the Segment Anything Model (SAM) 3 architecture on medical images paired with semantic conceptual labels, our MedSAM-3 enables medical Promptable Concept Segmentation (PCS), allowing precise targeting of anatomical structures via open-vocabulary text descriptions rather than solely geometric prompts. We further introduce the MedSAM-3 Agent, a framework that integrates Multimodal Large Language Models (MLLMs) to perform complex reasoning and iterative refinement in an agent-in-the-loop workflow. Comprehensive experiments across diverse medical imaging modalities, including X-ray, MRI, Ultrasound, CT, and video, demonstrate that our approach significantly outperforms existing specialist and foundation models. We will release our code and model at https://github.com/Joey-S-Liu/MedSAM3.

With the recent emergence of revolutionary autonomous agentic systems, research community is witnessing a significant shift from traditional static, passive, and domain-specific AI agents toward more dynamic, proactive, and generalizable agentic AI. Motivated by the growing interest in agentic AI and its potential trajectory toward AGI, we present a comprehensive survey on Agentic Multimodal Large Language Models (Agentic MLLMs). In this survey, we explore the emerging paradigm of agentic MLLMs, delineating their conceptual foundations and distinguishing characteristics from conventional MLLM-based agents. We establish a conceptual framework that organizes agentic MLLMs along three fundamental dimensions: (i) Agentic internal intelligence functions as the system's commander, enabling accurate long-horizon planning through reasoning, reflection, and memory; (ii) Agentic external tool invocation, whereby models proactively use various external tools to extend their problem-solving capabilities beyond their intrinsic knowledge; and (iii) Agentic environment interaction further situates models within virtual or physical environments, allowing them to take actions, adapt strategies, and sustain goal-directed behavior in dynamic real-world scenarios. To further accelerate research in this area for the community, we compile open-source training frameworks, training and evaluation datasets for developing agentic MLLMs. Finally, we review the downstream applications of agentic MLLMs and outline future research directions for this rapidly evolving field. To continuously track developments in this rapidly evolving field, we will also actively update a public repository at https://github.com/HJYao00/Awesome-Agentic-MLLMs.

Recent advancements in large language models (LLMs) have led to the creation of intelligent agents capable of performing complex tasks. This paper introduces a novel LLM-based multimodal agent framework designed to operate smartphone applications. Our framework enables the agent to operate smartphone applications through a simplified action space, mimicking human-like interactions such as tapping and swiping. This novel approach bypasses the need for system back-end access, thereby broadening its applicability across diverse apps. Central to our agent's functionality is its innovative learning method. The agent learns to navigate and use new apps either through autonomous exploration or by observing human demonstrations. This process generates a knowledge base that the agent refers to for executing complex tasks across different applications. To demonstrate the practicality of our agent, we conducted extensive testing over 50 tasks in 10 different applications, including social media, email, maps, shopping, and sophisticated image editing tools. The results affirm our agent's proficiency in handling a diverse array of high-level tasks.

The recent success of large vision language models shows great potential in driving the agent system operating on user interfaces. However, we argue that the power multimodal models like GPT-4V as a general agent on multiple operating systems across different applications is largely underestimated due to the lack of a robust screen parsing technique capable of: 1) reliably identifying interactable icons within the user interface, and 2) understanding the semantics of various elements in a screenshot and accurately associate the intended action with the corresponding region on the screen. To fill these gaps, we introduce OmniParser, a comprehensive method for parsing user interface screenshots into structured elements, which significantly enhances the ability of GPT-4V to generate actions that can be accurately grounded in the corresponding regions of the interface. We first curated an interactable icon detection dataset using popular webpages and an icon description dataset. These datasets were utilized to fine-tune specialized models: a detection model to parse interactable regions on the screen and a caption model to extract the functional semantics of the detected elements. OmniParser significantly improves GPT-4V's performance on ScreenSpot benchmark. And on Mind2Web and AITW benchmark, OmniParser with screenshot only input outperforms the GPT-4V baselines requiring additional information outside of screenshot.

While vision-language models (VLMs) have demonstrated remarkable performance across various tasks combining textual and visual information, they continue to struggle with fine-grained visual perception tasks that require detailed pixel-level analysis. Effectively eliciting comprehensive reasoning from VLMs on such intricate visual elements remains an open challenge. In this paper, we present VipAct, an agent framework that enhances VLMs by integrating multi-agent collaboration and vision expert models, enabling more precise visual understanding and comprehensive reasoning. VipAct consists of an orchestrator agent, which manages task requirement analysis, planning, and coordination, along with specialized agents that handle specific tasks such as image captioning and vision expert models that provide high-precision perceptual information. This multi-agent approach allows VLMs to better perform fine-grained visual perception tasks by synergizing planning, reasoning, and tool use. We evaluate VipAct on benchmarks featuring a diverse set of visual perception tasks, with experimental results demonstrating significant performance improvements over state-of-the-art baselines across all tasks. Furthermore, comprehensive ablation studies reveal the critical role of multi-agent collaboration in eliciting more detailed System-2 reasoning and highlight the importance of image input for task planning. Additionally, our error analysis identifies patterns of VLMs' inherent limitations in visual perception, providing insights into potential future improvements. VipAct offers a flexible and extensible framework, paving the way for more advanced visual perception systems across various real-world applications.

By leveraging tool-augmented Multimodal Large Language Models (MLLMs), multi-agent frameworks are driving progress in video understanding. However, most of them adopt static and non-learnable tool invocation mechanisms, which limit the discovery of diverse clues essential for robust perception and reasoning regarding temporally or spatially complex videos. To address this challenge, we propose a novel Multi-agent system for video understanding, namely VideoChat-M1. Instead of using a single or fixed policy, VideoChat-M1 adopts a distinct Collaborative Policy Planning (CPP) paradigm with multiple policy agents, which comprises three key processes. (1) Policy Generation: Each agent generates its unique tool invocation policy tailored to the user's query; (2) Policy Execution: Each agent sequentially invokes relevant tools to execute its policy and explore the video content; (3) Policy Communication: During the intermediate stages of policy execution, agents interact with one another to update their respective policies. Through this collaborative framework, all agents work in tandem, dynamically refining their preferred policies based on contextual insights from peers to effectively respond to the user's query. Moreover, we equip our CPP paradigm with a concise Multi-Agent Reinforcement Learning (MARL) method. Consequently, the team of policy agents can be jointly optimized to enhance VideoChat-M1's performance, guided by both the final answer reward and intermediate collaborative process feedback. Extensive experiments demonstrate that VideoChat-M1 achieves SOTA performance across eight benchmarks spanning four tasks. Notably, on LongVideoBench, our method outperforms the SOTA model Gemini 2.5 pro by 3.6% and GPT-4o by 15.6%.

Multimodal agents for computer use rely exclusively on primitive actions (click, type, scroll) that require accurate visual grounding and lengthy execution chains, leading to cascading failures and performance bottlenecks. While other agents leverage rich programmatic interfaces (APIs, MCP servers, tools), computer-use agents (CUAs) remain isolated from these capabilities. We present UltraCUA, a foundation model that bridges this gap through hybrid action -- seamlessly integrating GUI primitives with high-level programmatic tool calls. To achieve this, our approach comprises four key components: (1) an automated pipeline that scales programmatic tools from software documentation, open-source repositories, and code generation; (2) a synthetic data engine producing over 17,000 verifiable tasks spanning real-world computer-use scenarios; (3) a large-scale high-quality hybrid action trajectory collection with both low-level GUI actions and high-level programmatic tool calls; and (4) a two-stage training pipeline combining supervised fine-tuning with online reinforcement learning, enabling strategic alternation between low-level and high-level actions. Experiments with our 7B and 32B models demonstrate substantial improvements over state-of-the-art agents. On OSWorld, UltraCUA models achieve an average 22% relative improvement over base models, while being 11% faster in terms of steps. Out-of-domain evaluation on WindowsAgentArena shows our model reaches 21.7% success rate, outperforming baselines trained on Windows data. The hybrid action mechanism proves critical, reducing error propagation while maintaining execution efficiency.

Proteins are essential macromolecules defined by their amino acid sequences, which determine their three-dimensional structures and, consequently, their functions in all living organisms. Therefore, generative protein modeling necessitates a multimodal approach to simultaneously model, understand, and generate both sequences and structures. However, existing methods typically use separate models for each modality, limiting their ability to capture the intricate relationships between sequence and structure. This results in suboptimal performance in tasks that requires joint understanding and generation of both modalities. In this paper, we introduce DPLM-2, a multimodal protein foundation model that extends discrete diffusion protein language model (DPLM) to accommodate both sequences and structures. To enable structural learning with the language model, 3D coordinates are converted to discrete tokens using a lookup-free quantization-based tokenizer. By training on both experimental and high-quality synthetic structures, DPLM-2 learns the joint distribution of sequence and structure, as well as their marginals and conditionals. We also implement an efficient warm-up strategy to exploit the connection between large-scale evolutionary data and structural inductive biases from pre-trained sequence-based protein language models. Empirical evaluation shows that DPLM-2 can simultaneously generate highly compatible amino acid sequences and their corresponding 3D structures eliminating the need for a two-stage generation approach. Moreover, DPLM-2 demonstrates competitive performance in various conditional generation tasks, including folding, inverse folding, and scaffolding with multimodal motif inputs, as well as providing structure-aware representations for predictive tasks.

Spatio-temporal localization is vital for precise interactions across diverse domains, from biological research to autonomous navigation and interactive interfaces. Current video-based approaches, while proficient in tracking, lack the sophisticated reasoning capabilities of large language models, limiting their contextual understanding and generalization. We introduce VideoMolmo, a large multimodal model tailored for fine-grained spatio-temporal pointing conditioned on textual descriptions. Building upon the Molmo architecture, VideoMolmo incorporates a temporal module utilizing an attention mechanism to condition each frame on preceding frames, ensuring temporal consistency. Additionally, our novel temporal mask fusion pipeline employs SAM2 for bidirectional point propagation, significantly enhancing coherence across video sequences. This two-step decomposition, i.e., first using the LLM to generate precise pointing coordinates, then relying on a sequential mask-fusion module to produce coherent segmentation, not only simplifies the task for the language model but also enhances interpretability. Due to the lack of suitable datasets, we curate a comprehensive dataset comprising 72k video-caption pairs annotated with 100k object points. To evaluate the generalization of VideoMolmo, we introduce VPoS-Bench, a challenging out-of-distribution benchmark spanning five real-world scenarios: Cell Tracking, Egocentric Vision, Autonomous Driving, Video-GUI Interaction, and Robotics. We also evaluate our model on Referring Video Object Segmentation (Refer-VOS) and Reasoning VOS tasks. In comparison to existing models, VideoMolmo substantially improves spatio-temporal pointing accuracy and reasoning capability. Our code and models are publicly available at https://github.com/mbzuai-oryx/VideoMolmo.

Human communication is a complex and diverse process that not only involves multiple factors such as language, commonsense, and cultural backgrounds but also requires the participation of multimodal information, such as speech. Large Language Model (LLM)-based multi-agent systems have demonstrated promising performance in simulating human society. Can we leverage LLM-based multi-agent systems to simulate human communication? However, current LLM-based multi-agent systems mainly rely on text as the primary medium. In this paper, we propose SpeechAgents, a multi-modal LLM based multi-agent system designed for simulating human communication. SpeechAgents utilizes multi-modal LLM as the control center for individual agent and employes multi-modal signals as the medium for exchanged messages among agents. Additionally, we propose Multi-Agent Tuning to enhance the multi-agent capabilities of LLM without compromising general abilities. To strengthen and evaluate the effectiveness of human communication simulation, we build the Human-Communication Simulation Benchmark. Experimental results demonstrate that SpeechAgents can simulate human communication dialogues with consistent content, authentic rhythm, and rich emotions and demonstrate excellent scalability even with up to 25 agents, which can apply to tasks such as drama creation and audio novels generation. Code and models will be open-sourced at https://github. com/0nutation/SpeechAgents

Multi-modal large language models (MM-LLMs) have shown strong performance in medical image understanding and clinical reasoning. Recent medical agent systems extend them with tool use and multi-agent collaboration, enabling complex decision-making. However, these systems rely almost entirely on frontier models (e.g., GPT), whose API-based deployment incurs high cost, high latency, and privacy risks that conflict with on-premise clinical requirements. We present Meissa, a lightweight 4B-parameter medical MM-LLM that brings agentic capability offline. Instead of imitating static answers, Meissa learns both when to engage external interaction (strategy selection) and how to execute multi-step interaction (strategy execution) by distilling structured trajectories from frontier models. Specifically, we propose: (1) Unified trajectory modeling: trajectories (reasoning and action traces) are represented within a single state-action-observation formalism, allowing one model to generalize across heterogeneous medical environments. (2) Three-tier stratified supervision: the model's own errors trigger progressive escalation from direct reasoning to tool-augmented and multi-agent interaction, explicitly learning difficulty-aware strategy selection. (3) Prospective-retrospective supervision: pairing exploratory forward traces with hindsight-rationalized execution traces enables stable learning of effective interaction policies. Trained on 40K curated trajectories, Meissa matches or exceeds proprietary frontier agents in 10 of 16 evaluation settings across 13 medical benchmarks spanning radiology, pathology, and clinical reasoning. Using over 25x fewer parameters than typical frontier models like Gemini-3, Meissa operates fully offline with 22x lower end-to-end latency compared to API-based deployment. Data, models, and environments are released at https://github.com/Schuture/Meissa.

Large Multimodal Models (LMMs) exhibit impressive performance across various multimodal tasks. However, their effectiveness in cross-cultural contexts remains limited due to the predominantly Western-centric nature of most data and models. Conversely, multi-agent models have shown significant capability in solving complex tasks. Our study evaluates the collective performance of LMMs in a multi-agent interaction setting for the novel task of cultural image captioning. Our contributions are as follows: (1) We introduce MosAIC, a Multi-Agent framework to enhance cross-cultural Image Captioning using LMMs with distinct cultural personas; (2) We provide a dataset of culturally enriched image captions in English for images from China, India, and Romania across three datasets: GeoDE, GD-VCR, CVQA; (3) We propose a culture-adaptable metric for evaluating cultural information within image captions; and (4) We show that the multi-agent interaction outperforms single-agent models across different metrics, and offer valuable insights for future research. Our dataset and models can be accessed at https://github.com/MichiganNLP/MosAIC.

Despite advancements in Large Language Models (LLMs) and Large Multimodal Models (LMMs), their integration into language-grounded, human-like embodied agents remains incomplete, hindering complex real-life task performance in physical environments. Existing integrations often feature limited open sourcing, challenging collective progress in this field. We introduce LEGENT, an open, scalable platform for developing embodied agents using LLMs and LMMs. LEGENT offers a dual approach: a rich, interactive 3D environment with communicable and actionable agents, paired with a user-friendly interface, and a sophisticated data generation pipeline utilizing advanced algorithms to exploit supervision from simulated worlds at scale. In our experiments, an embryonic vision-language-action model trained on LEGENT-generated data surpasses GPT-4V in embodied tasks, showcasing promising generalization capabilities.

Cooperative perception through Vehicle-to-Everything (V2X) communication offers significant potential for enhancing vehicle perception by mitigating occlusions and expanding the field of view. However, past research has predominantly focused on improving accuracy metrics without addressing the crucial system-level considerations of efficiency, latency, and real-world deployability. Noticeably, most existing systems rely on full-precision models, which incur high computational and transmission costs, making them impractical for real-time operation in resource-constrained environments. In this paper, we introduce QuantV2X, the first fully quantized multi-agent system designed specifically for efficient and scalable deployment of multi-modal, multi-agent V2X cooperative perception. QuantV2X introduces a unified end-to-end quantization strategy across both neural network models and transmitted message representations that simultaneously reduces computational load and transmission bandwidth. Remarkably, despite operating under low-bit constraints, QuantV2X achieves accuracy comparable to full-precision systems. More importantly, when evaluated under deployment-oriented metrics, QuantV2X reduces system-level latency by 3.2times and achieves a +9.5 improvement in mAP30 over full-precision baselines. Furthermore, QuantV2X scales more effectively, enabling larger and more capable models to fit within strict memory budgets. These results highlight the viability of a fully quantized multi-agent intermediate fusion system for real-world deployment. The system will be publicly released to promote research in this field: https://github.com/ucla-mobility/QuantV2X.

Training effective AI agents for multi-turn interactions requires high-quality data that captures realistic human-agent dynamics, yet such data is scarce and expensive to collect manually. We introduce APIGen-MT, a two-phase framework that generates verifiable and diverse multi-turn agent data. In the first phase, our agentic pipeline produces detailed task blueprints with ground-truth actions, leveraging a committee of LLM reviewers and iterative feedback loops. These blueprints are then transformed into complete interaction trajectories through simulated human-agent interplay. We train a family of models -- the xLAM-2-fc-r series with sizes ranging from 1B to 70B parameters. Our models outperform frontier models such as GPT-4o and Claude 3.5 on tau-bench and BFCL benchmarks, with the smaller models surpassing their larger counterparts, particularly in multi-turn settings, while maintaining superior consistency across multiple trials. Comprehensive experiments demonstrate that our verified blueprint-to-details approach yields high-quality training data, enabling the development of more reliable, efficient, and capable agents. We open-source both the synthetic data collected and the trained xLAM-2-fc-r models to advance research in AI agents. Models are available on HuggingFace at https://huggingface.co/collections/Salesforce/xlam-2-67ef5be12949d8dcdae354c4 and project website is https://apigen-mt.github.io

Despite growing enthusiasm for Multi-Agent Systems (MAS), where multiple LLM agents collaborate to accomplish tasks, their performance gains across popular benchmarks remain minimal compared to single-agent frameworks. This gap highlights the need to analyze the challenges hindering MAS effectiveness. In this paper, we present the first comprehensive study of MAS challenges. We analyze five popular MAS frameworks across over 150 tasks, involving six expert human annotators. We identify 14 unique failure modes and propose a comprehensive taxonomy applicable to various MAS frameworks. This taxonomy emerges iteratively from agreements among three expert annotators per study, achieving a Cohen's Kappa score of 0.88. These fine-grained failure modes are organized into 3 categories, (i) specification and system design failures, (ii) inter-agent misalignment, and (iii) task verification and termination. To support scalable evaluation, we integrate MASFT with LLM-as-a-Judge. We also explore if identified failures could be easily prevented by proposing two interventions: improved specification of agent roles and enhanced orchestration strategies. Our findings reveal that identified failures require more complex solutions, highlighting a clear roadmap for future research. We open-source our dataset and LLM annotator.

Vision language models (VLMs) achieve strong performance on general image understanding but struggle to think with medical images, especially when performing multi-step reasoning through iterative visual interaction. Medical VLMs often rely on static visual embeddings and single-pass inference, preventing models from re-examining, verifying, or refining visual evidence during reasoning. While tool-integrated reasoning offers a promising path forward, open-source VLMs lack the training infrastructure to learn effective tool selection, invocation, and coordination in multi-modal medical reasoning. We introduce MedVistaGym, a scalable and interactive training environment that incentivizes tool-integrated visual reasoning for medical image analysis. MedVistaGym equips VLMs to determine when and which tools to invoke, localize task-relevant image regions, and integrate single or multiple sub-image evidence into interleaved multimodal reasoning within a unified, executable interface for agentic training. Using MedVistaGym, we train MedVistaGym-R1 to interleave tool use with agentic reasoning through trajectory sampling and end-to-end reinforcement learning. Across six medical VQA benchmarks, MedVistaGym-R1-8B exceeds comparably sized tool-augmented baselines by 19.10% to 24.21%, demonstrating that structured agentic training--not tool access alone--unlocks effective tool-integrated reasoning for medical image analysis.

Interactive and embodied tasks pose at least two fundamental challenges to existing Vision & Language (VL) models, including 1) grounding language in trajectories of actions and observations, and 2) referential disambiguation. To tackle these challenges, we propose an Embodied MultiModal Agent (EMMA): a unified encoder-decoder model that reasons over images and trajectories, and casts action prediction as multimodal text generation. By unifying all tasks as text generation, EMMA learns a language of actions which facilitates transfer across tasks. Different to previous modular approaches with independently trained components, we use a single multitask model where each task contributes to goal completion. EMMA performs on par with similar models on several VL benchmarks and sets a new state-of-the-art performance (36.81% success rate) on the Dialog-guided Task Completion (DTC), a benchmark to evaluate dialog-guided agents in the Alexa Arena

We present a single-turn agent for graphical user interface (GUI) interaction tasks, using Vision-Language Model Florence-2-Base. The agent's primary task is identifying the screen coordinates of the UI element corresponding to the user's command. It demonstrates strong performance on Screenspot and OmniAct, while maintaining a compact size of 0.27B parameters and minimal latency. Relevant improvement comes from multi-task training and MLLM-based data augmentation. Manually annotated corpora are scarce, but we show that MLLM augmentation might produce better results. On Screenspot and OmniAct, our model outperforms both GUI-specific models (e.g., SeeClick) and MLLMs (e.g., GPT-4V).

The recent success of large foundation models in artificial intelligence has prompted the emergence of chemical pre-trained models. Despite the growing interest in large molecular pre-trained models that provide informative representations for downstream tasks, attempts for multimodal pre-training approaches on the molecule domain were limited. To address this, we present a novel multimodal molecular pre-trained model that incorporates the modalities of structure and biochemical properties, drawing inspiration from recent advances in multimodal learning techniques. Our proposed model pipeline of data handling and training objectives aligns the structure/property features in a common embedding space, which enables the model to regard bidirectional information between the molecules' structure and properties. These contributions emerge synergistic knowledge, allowing us to tackle both multimodal and unimodal downstream tasks through a single model. Through extensive experiments, we demonstrate that our model shows remarkable capabilities in solving various meaningful chemical challenges, including conditional molecule generation, property prediction, molecule classification, and reaction prediction.

We propose MM-REACT, a system paradigm that integrates ChatGPT with a pool of vision experts to achieve multimodal reasoning and action. In this paper, we define and explore a comprehensive list of advanced vision tasks that are intriguing to solve, but may exceed the capabilities of existing vision and vision-language models. To achieve such advanced visual intelligence, MM-REACT introduces a textual prompt design that can represent text descriptions, textualized spatial coordinates, and aligned file names for dense visual signals such as images and videos. MM-REACT's prompt design allows language models to accept, associate, and process multimodal information, thereby facilitating the synergetic combination of ChatGPT and various vision experts. Zero-shot experiments demonstrate MM-REACT's effectiveness in addressing the specified capabilities of interests and its wide application in different scenarios that require advanced visual understanding. Furthermore, we discuss and compare MM-REACT's system paradigm with an alternative approach that extends language models for multimodal scenarios through joint finetuning. Code, demo, video, and visualization are available at https://multimodal-react.github.io/

The advancement of large language models (LLMs) leads to a new era marked by the development of autonomous applications in the real world, which drives innovation in the creation of advanced web-based agents. Existing web agents typically only handle one input modality and are evaluated only in simplified web simulators or static web snapshots, greatly limiting their applicability in real-world scenarios. To bridge this gap, we introduce WebVoyager, an innovative Large Multimodal Model (LMM) powered web agent that can complete user instructions end-to-end by interacting with real-world websites. Moreover, we propose a new evaluation protocol for web agents to address the challenges of automatic evaluation of open-ended web agent tasks, leveraging the robust multimodal comprehension capabilities of GPT-4V. We create a new benchmark by gathering real-world tasks from 15 widely used websites to evaluate our agents. We show that WebVoyager achieves a 55.7% task success rate, significantly surpassing the performance of both GPT-4 (All Tools) and the WebVoyager (text-only) setups, underscoring the exceptional capability of WebVoyager in practical applications. We found that our proposed automatic evaluation achieves 85.3% agreement with human judgment, paving the way for further development of web agents in a real-world setting.

Hit identification is a central challenge in early drug discovery, traditionally requiring substantial experimental resources. Recent advances in artificial intelligence, particularly large language models (LLMs), have enabled virtual screening methods that reduce costs and improve efficiency. However, the growing complexity of these tools has limited their accessibility to wet-lab researchers. Multi-agent systems offer a promising solution by combining the interpretability of LLMs with the precision of specialized models and tools. In this work, we present MADD, a multi-agent system that builds and executes customized hit identification pipelines from natural language queries. MADD employs four coordinated agents to handle key subtasks in de novo compound generation and screening. We evaluate MADD across seven drug discovery cases and demonstrate its superior performance compared to existing LLM-based solutions. Using MADD, we pioneer the application of AI-first drug design to five biological targets and release the identified hit molecules. Finally, we introduce a new benchmark of query-molecule pairs and docking scores for over three million compounds to contribute to the agentic future of drug design.

Protein biology focuses on the intricate relationships among sequences, structures, and functions. Deciphering protein functions is crucial for understanding biological processes, advancing drug discovery, and enabling synthetic biology applications. Since protein sequences determine tertiary structures, which in turn govern functions, integrating sequence and structure information is essential for accurate prediction of protein functions. Traditional protein language models (pLMs) have advanced protein-related tasks by learning representations from large-scale sequence and structure data. However, pLMs are limited in integrating broader contextual knowledge, particularly regarding functional modalities that are fundamental to protein biology. In contrast, large language models (LLMs) have exhibited outstanding performance in contextual understanding, reasoning, and generation across diverse domains. Leveraging these capabilities, STELLA is proposed as a multimodal LLM integrating protein sequence-structure representations with general knowledge to address protein function prediction. Through multimodal instruction tuning (MMIT) using the proposed OPI-Struc dataset, STELLA achieves state-of-the-art performance in two function-related tasks-functional description prediction (FP) and enzyme-catalyzed reaction prediction (EP). This study highlights the potential of multimodal LLMs as an alternative paradigm to pLMs to advance protein biology research.

Multimodal protein language models deliver strong performance on mutation-effect prediction, but training such models from scratch demands substantial computational resources. In this paper, we propose a fine-tuning framework called InstructPLM-mu and try to answer a question: Can multimodal fine-tuning of a pretrained, sequence-only protein language model match the performance of models trained end-to-end? Surprisingly, our experiments show that fine-tuning ESM2 with structural inputs can reach performance comparable to ESM3. To understand how this is achieved, we systematically compare three different feature-fusion designs and fine-tuning recipes. Our results reveal that both the fusion method and the tuning strategy strongly affect final accuracy, indicating that the fine-tuning process is not trivial. We hope this work offers practical guidance for injecting structure into pretrained protein language models and motivates further research on better fusion mechanisms and fine-tuning protocols.

We introduce GenAgent, unifying visual understanding and generation through an agentic multimodal model. Unlike unified models that face expensive training costs and understanding-generation trade-offs, GenAgent decouples these capabilities through an agentic framework: understanding is handled by the multimodal model itself, while generation is achieved by treating image generation models as invokable tools. Crucially, unlike existing modular systems constrained by static pipelines, this design enables autonomous multi-turn interactions where the agent generates multimodal chains-of-thought encompassing reasoning, tool invocation, judgment, and reflection to iteratively refine outputs. We employ a two-stage training strategy: first, cold-start with supervised fine-tuning on high-quality tool invocation and reflection data to bootstrap agent behaviors; second, end-to-end agentic reinforcement learning combining pointwise rewards (final image quality) and pairwise rewards (reflection accuracy), with trajectory resampling for enhanced multi-turn exploration. GenAgent significantly boosts base generator(FLUX.1-dev) performance on GenEval++ (+23.6\%) and WISE (+14\%). Beyond performance gains, our framework demonstrates three key properties: 1) cross-tool generalization to generators with varying capabilities, 2) test-time scaling with consistent improvements across interaction rounds, and 3) task-adaptive reasoning that automatically adjusts to different tasks. Our code will be available at https://github.com/deep-kaixun/GenAgent{this url}.

Existing Multimodal Large Language Models (MLLMs) encounter significant challenges in modeling the temporal context within long videos. Currently, mainstream Agent-based methods use external tools (e.g., search engine, memory banks, OCR, retrieval models) to assist a single MLLM in answering long video questions. Despite such tool-based support, a solitary MLLM still offers only a partial understanding of long videos, resulting in limited performance. In order to better address long video tasks, we introduce LVAgent, the first framework enabling multi-round dynamic collaboration of MLLM agents in long video understanding. Our methodology consists of four key steps: 1. Selection: We pre-select appropriate agents from the model library to form optimal agent teams based on different tasks. 2. Perception: We design an effective retrieval scheme for long videos, improving the coverage of critical temporal segments while maintaining computational efficiency. 3. Action: Agents answer long video-related questions and exchange reasons. 4. Reflection: We evaluate the performance of each agent in each round of discussion and optimize the agent team for dynamic collaboration. The agents iteratively refine their answers by multi-round dynamical collaboration of MLLM agents. LVAgent is the first agent system method that outperforms all closed-source models (including GPT-4o) and open-source models (including InternVL-2.5 and Qwen2-VL) in the long video understanding tasks. Our LVAgent achieves an accuracy of 80% on four mainstream long video understanding tasks. Notably, on the LongVideoBench dataset, LVAgent improves accuracy by up to 13.3% compared with SOTA.

Multimodal protein language models (PLMs) integrate sequence and token-based structural information, serving as a powerful foundation for protein modeling, generation, and design. However, the reliance on tokenizing 3D structures into discrete tokens causes substantial loss of fidelity about fine-grained structural details and correlations. In this paper, we systematically elucidate the design space of multimodal PLMs to overcome their limitations. We identify tokenization loss and inaccurate structure token predictions by the PLMs as major bottlenecks. To address these, our proposed design space covers improved generative modeling, structure-aware architectures and representation learning, and data exploration. Our advancements approach finer-grained supervision, demonstrating that token-based multimodal PLMs can achieve robust structural modeling. The effective design methods dramatically improve the structure generation diversity, and notably, folding abilities of our 650M model by reducing the RMSD from 5.52 to 2.36 on PDB testset, even outperforming 3B baselines and on par with the specialized folding models.

Multimodal deep search agents have shown great potential in solving complex tasks by iteratively collecting textual and visual evidence. However, managing the heterogeneous information and high token costs associated with multimodal inputs over long horizons remains a critical challenge, as existing methods often suffer from context explosion or the loss of crucial visual signals. To address this, we propose a novel Long-horizon MultiModal deep search framework, named LMM-Searcher, centered on a file-based visual representation mechanism. By offloading visual assets to an external file system and mapping them to lightweight textual identifiers (UIDs), our approach mitigates context overhead while preserving multimodal information for future access. We equip the agent with a tailored fetch-image tool, enabling a progressive, on-demand visual loading strategy for active perception. Furthermore, we introduce a data synthesis pipeline designed to generate queries requiring complex cross-modal multi-hop reasoning. Using this pipeline, we distill 12K high-quality trajectories to fine-tune Qwen3-VL-Thinking-30A3B into a specialized multimodal deep search agent. Extensive experiments across four benchmarks demonstrate that our method successfully scales to 100-turn search horizons, achieving state-of-the-art performance among open-source models on challenging long-horizon benchmarks like MM-BrowseComp and MMSearch-Plus, while also exhibiting strong generalizability across different base models. Our code will be released in https://github.com/RUCAIBox/LMM-Searcher.

Can generative agents be trusted in multimodal environments? Despite advances in large language and vision-language models that enable agents to act autonomously and pursue goals in rich settings, their ability to reason about safety, coherence, and trust across modalities remains limited. We introduce a reproducible simulation framework for evaluating agents along three dimensions: (1) safety improvement over time, including iterative plan revisions in text-visual scenarios; (2) detection of unsafe activities across multiple categories of social situations; and (3) social dynamics, measured as interaction counts and acceptance ratios of social exchanges. Agents are equipped with layered memory, dynamic planning, multimodal perception, and are instrumented with SocialMetrics, a suite of behavioral and structural metrics that quantifies plan revisions, unsafe-to-safe conversions, and information diffusion across networks. Experiments show that while agents can detect direct multimodal contradictions, they often fail to align local revisions with global safety, reaching only a 55 percent success rate in correcting unsafe plans. Across eight simulation runs with three models - Claude, GPT-4o mini, and Qwen-VL - five agents achieved average unsafe-to-safe conversion rates of 75, 55, and 58 percent, respectively. Overall performance ranged from 20 percent in multi-risk scenarios with GPT-4o mini to 98 percent in localized contexts such as fire/heat with Claude. Notably, 45 percent of unsafe actions were accepted when paired with misleading visuals, showing a strong tendency to overtrust images. These findings expose critical limitations in current architectures and provide a reproducible platform for studying multimodal safety, coherence, and social dynamics.

Text-to-image (T2I) models are well known for their ability to produce highly realistic images, while multimodal large language models (MLLMs) are renowned for their proficiency in understanding and integrating multiple modalities. However, currently there is no straightforward and efficient framework to transfer the multimodal comprehension abilities of MLLMs to T2I models to enable them to understand multimodal inputs. In this paper, we propose the X2I framework, which endows Diffusion Transformer (DiT) models with the capability to comprehend various modalities, including multilingual text, screenshot documents, images, videos, and audio. X2I is trained using merely 100K English corpus with 160 GPU hours. Building on the DiT teacher model, we adopt an innovative distillation method to extract the inference capabilities of the teacher model and design a lightweight AlignNet structure to serve as an intermediate bridge. Compared to the teacher model, X2I shows a decrease in performance degradation of less than 1\% while gaining various multimodal understanding abilities, including multilingual to image, image to image, image-text to image, video to image, audio to image, and utilizing creative fusion to enhance imagery. Furthermore, it is applicable for LoRA training in the context of image-text to image generation, filling a void in the industry in this area. We further design a simple LightControl to enhance the fidelity of instructional image editing. Finally, extensive experiments demonstrate the effectiveness, efficiency, multifunctionality, and transferability of our X2I. The open-source code and checkpoints for X2I can be found at the following link: https://github.com/OPPO-Mente-Lab/X2I.

Protein-protein interaction (PPI) modeling has been widely studied as a binary or multi-label classification task. While emerging multimodal large language models (LLMs) can now describe single proteins, they remain unable to generate free-form descriptions of interactions between protein pairs. Moving beyond controlled vocabulary annotations, we propose to model PPI using free-text description, enabling richer expressiveness, improved interpretability, and better integration with literature knowledge base. We present PPI2Text, a multimodal LLM for free-form PPI captioning from amino acid sequences, that encodes each protein using ESM3 encoder, constructs a pair map from the two representations to capture interactions across all residue pairs, and autoregressively generates descriptions using a Qwen3 language decoder. We further introduce PaCo-RoPE, a coordinate-aligned positional encoding that aligns each axis of the pair grid with the residue positions of the corresponding protein. In addition, we release PPI2Text-Dataset, a 351k-pair corpus of free-form PPI descriptions aggregated from ten curated biological databases and further synthesized with Gemini under evidence-tiered prompting. PPI2Text consistently outperforms strong baselines across multiple ablation settings and evaluation protocols. It not only achieves higher scores on linguistic metrics against synthesized references, but also excels on factuality metrics, where an LLM-based judge evaluates outputs against raw biological evidence.

Training a unified model integrating video-to-audio (V2A), text-to-audio (T2A), and joint video-text-to-audio (VT2A) generation offers significant application flexibility, yet faces two unexplored foundational challenges: (1) the scarcity of high-quality audio captions with tight A-V-T alignment, leading to severe semantic conflict between multimodal conditions, and (2) cross-task and intra-task competition, manifesting as an adverse V2A-T2A performance trade-off and modality bias in the VT2A task. First, to address data scarcity, we introduce SoundAtlas, a large-scale dataset (470k pairs) that significantly outperforms existing benchmarks and even human experts in quality. Powered by a novel agentic pipeline, it integrates Vision-to-Language Compression to mitigate visual bias of MLLMs, a Junior-Senior Agent Handoff for a 5 times cost reduction, and rigorous Post-hoc Filtering to ensure fidelity. Consequently, SoundAtlas delivers semantically rich and temporally detailed captions with tight V-A-T alignment. Second, we propose Omni2Sound, a unified VT2A diffusion model supporting flexible input modalities. To resolve the inherent cross-task and intra-task competition, we design a three-stage multi-task progressive training schedule that converts cross-task competition into joint optimization and mitigates modality bias in the VT2A task, maintaining both audio-visual alignment and off-screen audio generation faithfulness. Finally, we construct VGGSound-Omni, a comprehensive benchmark for unified evaluation, including challenging off-screen tracks. With a standard DiT backbone, Omni2Sound achieves unified SOTA performance across all three tasks within a single model, demonstrating strong generalization across benchmarks with heterogeneous input conditions. The project page is at https://swapforward.github.io/Omni2Sound.

A generalist robotic policy needs both semantic understanding for task planning and the ability to interact with the environment through predictive capabilities. To tackle this, we present MM-ACT, a unified Vision-Language-Action (VLA) model that integrates text, image, and action in shared token space and performs generation across all three modalities. MM-ACT adopts a re-mask parallel decoding strategy for text and image generation, and employs a one-step parallel decoding strategy for action generation to improve efficiency. We introduce Context-Shared Multimodal Learning, a unified training paradigm that supervises generation in all three modalities from a shared context, enhancing action generation through cross-modal learning. Experiments were conducted on the LIBERO simulation and Franka real-robot setups as well as RoboTwin2.0 to assess in-domain and out-of-domain performances respectively. Our approach achieves a success rate of 96.3% on LIBERO, 72.0% across three tasks of real Franka, and 52.38% across eight bimanual tasks of RoboTwin2.0 with an additional gain of 9.25% from cross-modal learning. We release our codes, models and data at https://github.com/HHYHRHY/MM-ACT.

Mobile GUI agents aim to autonomously complete user-instructed tasks across mobile apps. Recent advances in Multimodal Large Language Models (MLLMs) enable these agents to interpret UI screens, identify actionable elements, and perform interactions such as tapping or typing. However, existing agents remain reactive: they reason only over the current screen and lack a structured model of app navigation flow, limiting their ability to understand context, detect unexpected outcomes, and recover from errors. We present MAPLE, a state-aware multi-agent framework that abstracts app interactions as a Finite State Machine (FSM). We computationally model each UI screen as a discrete state and user actions as transitions, allowing the FSM to provide a structured representation of the app execution. MAPLE consists of specialized agents responsible for four phases of task execution: planning, execution, verification, error recovery, and knowledge retention. These agents collaborate to dynamically construct FSMs in real time based on perception data extracted from the UI screen, allowing the GUI agents to track navigation progress and flow, validate action outcomes through pre- and post-conditions of the states, and recover from errors by rolling back to previously stable states. Our evaluation results on two challenging cross-app benchmarks, Mobile-Eval-E and SPA-Bench, show that MAPLE outperforms the state-of-the-art baseline, improving task success rate by up to 12%, recovery success by 13.8%, and action accuracy by 6.5%. Our results highlight the importance of structured state modeling in guiding mobile GUI agents during task execution. Moreover, our FSM representation can be integrated into future GUI agent architectures as a lightweight, model-agnostic memory layer to support structured planning, execution verification, and error recovery.

Recent progress in multimodal large language models (MLLMs) has demonstrated promising performance on medical benchmarks and in preliminary trials as clinical assistants. Yet, our pilot audit of diagnostic cases uncovers a critical failure mode: instability in early evidence interpretation precedes hallucination, creating branching reasoning trajectories that cascade into globally inconsistent conclusions. This highlights the need for clinical reasoning agents that constrain stochasticity and hallucination while producing auditable decision flows. We introduce MedMMV, a controllable multimodal multi-agent framework for reliable and verifiable clinical reasoning. MedMMV stabilizes reasoning through diversified short rollouts, grounds intermediate steps in a structured evidence graph under the supervision of a Hallucination Detector, and aggregates candidate paths with a Combined Uncertainty scorer. On six medical benchmarks, MedMMV improves accuracy by up to 12.7% and, more critically, demonstrates superior reliability. Blind physician evaluations confirm that MedMMV substantially increases reasoning truthfulness without sacrificing informational content. By controlling instability through a verifiable, multi-agent process, our framework provides a robust path toward deploying trustworthy AI systems in high-stakes domains like clinical decision support.

A multi-agent AI system (MAS) is composed of multiple autonomous agents that interact, exchange information, and make decisions based on internal generative models. Recent advances in large language models and tool-using agents have made MAS increasingly practical in areas like scientific discovery and collaborative automation. However, key questions remain: When are MAS more effective than single-agent systems? What new safety risks arise from agent interactions? And how should we evaluate their reliability and structure? This paper outlines a formal framework for analyzing MAS, focusing on two core aspects: effectiveness and safety. We explore whether MAS truly improve robustness, adaptability, and performance, or merely repackage known techniques like ensemble learning. We also study how inter-agent dynamics may amplify or suppress system vulnerabilities. While MAS are relatively new to the signal processing community, we envision them as a powerful abstraction that extends classical tools like distributed estimation and sensor fusion to higher-level, policy-driven inference. Through experiments on data science automation, we highlight the potential of MAS to reshape how signal processing systems are designed and trusted.

Multimodal large language models (MLLMs) have enabled LLM-based agents to directly interact with application user interfaces (UIs), enhancing agents' performance in complex tasks. However, these agents often suffer from high latency and low reliability due to the extensive sequential UI interactions. To address this issue, we propose AXIS, a novel LLM-based agents framework prioritize actions through application programming interfaces (APIs) over UI actions. This framework also facilitates the creation and expansion of APIs through automated exploration of applications. Our experiments on Office Word demonstrate that AXIS reduces task completion time by 65%-70% and cognitive workload by 38%-53%, while maintaining accuracy of 97%-98% compare to humans. Our work contributes to a new human-agent-computer interaction (HACI) framework and a fresh UI design principle for application providers in the era of LLMs. It also explores the possibility of turning every applications into agents, paving the way towards an agent-centric operating system (Agent OS).

We present GLM-5V-Turbo, a step toward native foundation models for multimodal agents. As foundation models are increasingly deployed in real environments, agentic capability depends not only on language reasoning, but also on the ability to perceive, interpret, and act over heterogeneous contexts such as images, videos, webpages, documents, GUIs. GLM-5V-Turbo is built around this objective: multimodal perception is integrated as a core component of reasoning, planning, tool use, and execution, rather than as an auxiliary interface to a language model. This report summarizes the main improvements behind GLM-5V-Turbo across model design, multimodal training, reinforcement learning, toolchain expansion, and integration with agent frameworks. These developments lead to strong performance in multimodal coding, visual tool use, and framework-based agentic tasks, while preserving competitive text-only coding capability. More importantly, our development process offers practical insights for building multimodal agents, highlighting the central role of multimodal perception, hierarchical optimization, and reliable end-to-end verification.

Mobile device agent based on Multimodal Large Language Models (MLLM) is becoming a popular application. In this paper, we introduce Mobile-Agent, an autonomous multi-modal mobile device agent. Mobile-Agent first leverages visual perception tools to accurately identify and locate both the visual and textual elements within the app's front-end interface. Based on the perceived vision context, it then autonomously plans and decomposes the complex operation task, and navigates the mobile Apps through operations step by step. Different from previous solutions that rely on XML files of Apps or mobile system metadata, Mobile-Agent allows for greater adaptability across diverse mobile operating environments in a vision-centric way, thereby eliminating the necessity for system-specific customizations. To assess the performance of Mobile-Agent, we introduced Mobile-Eval, a benchmark for evaluating mobile device operations. Based on Mobile-Eval, we conducted a comprehensive evaluation of Mobile-Agent. The experimental results indicate that Mobile-Agent achieved remarkable accuracy and completion rates. Even with challenging instructions, such as multi-app operations, Mobile-Agent can still complete the requirements. Code and model will be open-sourced at https://github.com/X-PLUG/MobileAgent.

Recent advances in operating system (OS) agents enable vision-language models to interact directly with the graphical user interface of an OS. These multimodal OS agents autonomously perform computer-based tasks in response to a single prompt via application programming interfaces (APIs). Such APIs typically support low-level operations, including mouse clicks, keyboard inputs, and screenshot captures. We introduce a novel attack vector: malicious image patches (MIPs) that have been adversarially perturbed so that, when captured in a screenshot, they cause an OS agent to perform harmful actions by exploiting specific APIs. For instance, MIPs embedded in desktop backgrounds or shared on social media can redirect an agent to a malicious website, enabling further exploitation. These MIPs generalise across different user requests and screen layouts, and remain effective for multiple OS agents. The existence of such attacks highlights critical security vulnerabilities in OS agents, which should be carefully addressed before their widespread adoption.

The integration of multimodal data including pathology images and gene profiles is widely applied in precise survival prediction. Despite recent advances in multimodal survival models, collecting complete modalities for multimodal fusion still poses a significant challenge, hindering their application in clinical settings. Current approaches tackling incomplete modalities often fall short, as they typically compensate for only a limited part of the knowledge of missing modalities. To address this issue, we propose a Distilled Prompt Learning framework (DisPro) to utilize the strong robustness of Large Language Models (LLMs) to missing modalities, which employs two-stage prompting for compensation of comprehensive information for missing modalities. In the first stage, Unimodal Prompting (UniPro) distills the knowledge distribution of each modality, preparing for supplementing modality-specific knowledge of the missing modality in the subsequent stage. In the second stage, Multimodal Prompting (MultiPro) leverages available modalities as prompts for LLMs to infer the missing modality, which provides modality-common information. Simultaneously, the unimodal knowledge acquired in the first stage is injected into multimodal inference to compensate for the modality-specific knowledge of the missing modality. Extensive experiments covering various missing scenarios demonstrated the superiority of the proposed method. The code is available at https://github.com/Innse/DisPro.

In large multimodal models (LMMs), the perception of non-language modalities (e.g., visual representations) is usually not on par with the large language models (LLMs)' powerful reasoning capabilities, deterring LMMs' performance on challenging downstream tasks. This weakness has been recently mitigated by replacing the vision encoder with a mixture-of-experts (MoE), which provides rich, multi-granularity, and diverse representations required by diverse downstream tasks. The performance of multimodal MoE largely depends on its router, which reweights and mixes the representations of different experts for each input. However, we find that the end-to-end trained router does not always produce the optimal routing weights for every test sample. To bridge the gap, we propose a novel and efficient method "Re-Routing in Test-Time(R2-T2) that locally optimizes the vector of routing weights in test-time by moving it toward those vectors of the correctly predicted samples in a neighborhood of the test sample. We propose three R2-T2 strategies with different optimization objectives and neighbor-search spaces. R2-T2 consistently and greatly improves state-of-the-art LMMs' performance on challenging benchmarks of diverse tasks, without training any base-model parameters.

Although LLMs demonstrate proficiency in several text-based reasoning and planning tasks, their implementation in robotics control is constrained by significant deficiencies: (1) LLM agents are designed to work mainly with textual inputs rather than visual conditions; (2) Current multimodal agents treat LLMs as static planners, which separates their reasoning from environment dynamics, resulting in actions that do not take domain-specific knowledge into account; and (3) LLMs are not designed to learn from visual interactions, which makes it harder for them to make better policies for specific domains. In this paper, we introduce EMAC+, an Embodied Multimodal Agent that collaboratively integrates LLM and VLM via a bidirectional training paradigm. Unlike existing methods, EMAC+ dynamically refines high-level textual plans generated by an LLM using real-time feedback from a VLM executing low-level visual control tasks. We address critical limitations of previous models by enabling the LLM to internalize visual environment dynamics directly through interactive experience, rather than relying solely on static symbolic mappings. Extensive experimental evaluations on ALFWorld and RT-1 benchmarks demonstrate that EMAC+ achieves superior task performance, robustness against noisy observations, and efficient learning. We also conduct thorough ablation studies and provide detailed analyses of success and failure cases.

Although artificial intelligence (AI) has made significant progress in understanding molecules in a wide range of fields, existing models generally acquire the single cognitive ability from the single molecular modality. Since the hierarchy of molecular knowledge is profound, even humans learn from different modalities including both intuitive diagrams and professional texts to assist their understanding. Inspired by this, we propose a molecular multimodal foundation model which is pretrained from molecular graphs and their semantically related textual data (crawled from published Scientific Citation Index papers) via contrastive learning. This AI model represents a critical attempt that directly bridges molecular graphs and natural language. Importantly, through capturing the specific and complementary information of the two modalities, our proposed model can better grasp molecular expertise. Experimental results show that our model not only exhibits promising performance in cross-modal tasks such as cross-modal retrieval and molecule caption, but also enhances molecular property prediction and possesses capability to generate meaningful molecular graphs from natural language descriptions. We believe that our model would have a broad impact on AI-empowered fields across disciplines such as biology, chemistry, materials, environment, and medicine, among others.

Understanding the 3D structures of protein multimers is crucial, as they play a vital role in regulating various cellular processes. It has been empirically confirmed that the multimer structure prediction~(MSP) can be well handled in a step-wise assembly fashion using provided dimer structures and predicted protein-protein interactions~(PPIs). However, due to the biological gap in the formation of dimers and larger multimers, directly applying PPI prediction techniques can often cause a poor generalization to the MSP task. To address this challenge, we aim to extend the PPI knowledge to multimers of different scales~(i.e., chain numbers). Specifically, we propose \textsc{PromptMSP}, a pre-training and Prompt tuning framework for Multimer Structure Prediction. First, we tailor the source and target tasks for effective PPI knowledge learning and efficient inference, respectively. We design PPI-inspired prompt learning to narrow the gaps of two task formats and generalize the PPI knowledge to multimers of different scales. We provide a meta-learning strategy to learn a reliable initialization of the prompt model, enabling our prompting framework to effectively adapt to limited data for large-scale multimers. Empirically, we achieve both significant accuracy (RMSD and TM-Score) and efficiency improvements compared to advanced MSP models. The code, data and checkpoints are released at https://github.com/zqgao22/PromptMSP.

Generating scientific manuscripts requires maintaining alignment between narrative reasoning, experimental evidence, and visual artifacts across the document lifecycle. Existing language-model generation pipelines rely on unconstrained text synthesis with validation applied only after generation, often producing structural drift, missing figures or tables, and cross-section inconsistencies. We introduce Story2Proposal, a contract-governed multi-agent framework that converts a research story into a structured manuscript through coordinated agents operating under a persistent shared visual contract. The system organizes architect, writer, refiner, and renderer agents around a contract state that tracks section structure and registered visual elements, while evaluation agents supply feedback in a generate evaluate adapt loop that updates the contract during generation. Experiments on tasks derived from the Jericho research corpus show that Story2Proposal achieved an expert evaluation score of 6.145 versus 3.963 for DirectChat (+2.182) across GPT, Claude, Gemini, and Qwen backbones. Compared with the structured generation baseline Fars, Story2Proposal obtained an average score of 5.705 versus 5.197, indicating improved structural consistency and visual alignment.

The progress of autonomous web navigation has been hindered by the dependence on billions of exploratory interactions via online reinforcement learning, and domain-specific model designs that make it difficult to leverage generalization from rich out-of-domain data. In this work, we study data-driven offline training for web agents with vision-language foundation models. We propose an instruction-following multimodal agent, WebGUM, that observes both webpage screenshots and HTML pages and outputs web navigation actions, such as click and type. WebGUM is trained by jointly finetuning an instruction-finetuned language model and a vision transformer on a large corpus of demonstrations. We empirically demonstrate this recipe improves the agent's ability of grounded visual perception, HTML comprehension and multi-step reasoning, outperforming prior works by a significant margin. On the MiniWoB benchmark, we improve over the previous best offline methods by more than 31.9%, being close to reaching online-finetuned SoTA. On the WebShop benchmark, our 3-billion-parameter model achieves superior performance to the existing SoTA, PaLM-540B. We also collect 347K high-quality demonstrations using our trained models, 38 times larger than prior work, and make them available to promote future research in this direction.

With the surge in the development of large language models, embodied intelligence has attracted increasing attention. Nevertheless, prior works on embodied intelligence typically encode scene or historical memory in an unimodal manner, either visual or linguistic, which complicates the alignment of the model's action planning with embodied control. To overcome this limitation, we introduce the Multimodal Embodied Interactive Agent (MEIA), capable of translating high-level tasks expressed in natural language into a sequence of executable actions. Specifically, we propose a novel Multimodal Environment Memory (MEM) module, facilitating the integration of embodied control with large models through the visual-language memory of scenes. This capability enables MEIA to generate executable action plans based on diverse requirements and the robot's capabilities. We conduct experiments in a dynamic virtual cafe environment, utilizing multiple large models through zero-shot learning, and carefully design scenarios for various situations. The experimental results showcase the promising performance of our MEIA in various embodied interactive tasks.

Predicting protein function from sequence is a central challenge in computational biology. While existing methods rely heavily on structured ontologies or similarity-based techniques, they often lack the flexibility to express structure-free functional descriptions and novel biological functions. In this work, we introduce Prot2Text-V2, a novel multimodal sequence-to-text model that generates free-form natural language descriptions of protein function directly from amino acid sequences. Our method combines a protein language model as a sequence encoder (ESM-3B) and a decoder-only language model (LLaMA-3.1-8B-Instruct) through a lightweight nonlinear modality projector. A key innovation is our Hybrid Sequence-level Contrastive Alignment Learning (H-SCALE), which improves cross-modal learning by matching mean- and std-pooled protein embeddings with text representations via contrastive loss. After the alignment phase, we apply instruction-based fine-tuning using LoRA on the decoder to teach the model how to generate accurate protein function descriptions conditioned on the protein sequence. We train Prot2Text-V2 on about 250K curated entries from SwissProt and evaluate it under low-homology conditions, where test sequences have low similarity with training samples. Prot2Text-V2 consistently outperforms traditional and LLM-based baselines across various metrics.

Multimodal agentic pipelines are transforming human-computer interaction by enabling efficient and accessible automation of complex, real-world tasks. However, recent efforts have focused on short-horizon or general-purpose applications (e.g., mobile or desktop interfaces), leaving long-horizon automation for domain-specific systems, particularly in healthcare, largely unexplored. To address this, we introduce CareFlow, a high-quality human-annotated benchmark comprising complex, long-horizon software workflows across medical annotation tools, DICOM viewers, EHR systems, and laboratory information systems. On this benchmark, existing vision-language models (VLMs) perform poorly, struggling with long-horizon reasoning and multi-step interactions in medical contexts. To overcome this, we propose CarePilot, a multi-agent framework based on the actor-critic paradigm. The Actor integrates tool grounding with dual-memory mechanisms (long-term and short-term experience) to predict the next semantic action from the visual interface and system state. The Critic evaluates each action, updates memory based on observed effects, and either executes or provides corrective feedback to refine the workflow. Through iterative agentic simulation, the Actor learns to perform more robust and reasoning-aware predictions during inference. Our experiments show that CarePilot achieves state-of-the-art performance, outperforming strong closed-source and open-source multimodal baselines by approximately 15.26% and 3.38%, respectively, on our benchmark and out-of-distribution dataset.

Most existing GUI agents typically depend on non-vision inputs like HTML source code or accessibility trees, limiting their flexibility across diverse software environments and platforms. Current multimodal large language models (MLLMs), which excel at using vision to ground real-world objects, offer a potential alternative. However, they often struggle with accurately localizing GUI elements -- a critical requirement for effective GUI automation -- due to the semantic gap between real-world objects and GUI elements. In this work, we introduce Ponder & Press, a divide-and-conquer framework for general computer control using only visual input. Our approach combines an general-purpose MLLM as an 'interpreter', responsible for translating high-level user instructions into detailed action descriptions, with a GUI-specific MLLM as a 'locator' that precisely locates GUI elements for action placement. By leveraging a purely visual input, our agent offers a versatile, human-like interaction paradigm applicable to a wide range of applications. Ponder & Press locator outperforms existing models by +22.5% on the ScreenSpot GUI grounding benchmark. Both offline and interactive agent benchmarks across various GUI environments -- including web pages, desktop software, and mobile UIs -- demonstrate that Ponder & Press framework achieves state-of-the-art performance, highlighting the potential of visual GUI agents. Refer to the project homepage https://invinciblewyq.github.io/ponder-press-page/

Recent vision-language models have strong perceptual ability but their implicit reasoning is hard to explain and easily generates hallucinations on complex queries. Compositional methods improve interpretability, but most rely on a single agent or hand-crafted pipeline and cannot decide when to collaborate across complementary agents or compete among overlapping ones. We introduce MATA (Multi-Agent hierarchical Trainable Automaton), a multi-agent system presented as a hierarchical finite-state automaton for visual reasoning whose top-level transitions are chosen by a trainable hyper agent. Each agent corresponds to a state in the hyper automaton, and runs a small rule-based sub-automaton for reliable micro-control. All agents read and write a shared memory, yielding transparent execution history. To supervise the hyper agent's transition policy, we build transition-trajectory trees and transform to memory-to-next-state pairs, forming the MATA-SFT-90K dataset for supervised finetuning (SFT). The finetuned LLM as the transition policy understands the query and the capacity of agents, and it can efficiently choose the optimal agent to solve the task. Across multiple visual reasoning benchmarks, MATA achieves the state-of-the-art results compared with monolithic and compositional baselines. The code and dataset are available at https://github.com/ControlNet/MATA.

Towards an embodied generalist for real-world interaction, Multimodal Large Language Model (MLLM) agents still suffer from challenging latency, sparse feedback, and irreversible mistakes. Video games offer an ideal testbed with rich visual observations and closed-loop interaction, demanding fine-grained perception, long-horizon planning, and precise control. However, systematically evaluating these capabilities is currently hindered by heterogeneous action interfaces and heuristic verification. To this end, we introduce GameWorld, a benchmark designed for standardized and verifiable evaluation of MLLMs as generalist game agents in browser environments. Two game agent interfaces are studied: (i) computer-use agents that directly emit keyboard and mouse controls, and (ii) generalist multimodal agents that act in a semantic action space via deterministic Semantic Action Parsing. GameWorld contains 34 diverse games and 170 tasks, each paired with state-verifiable metrics for outcome-based evaluation. The results across 18 model-interface pairs suggest that even the best performing agent is far from achieving human capabilities on video games. Extensive experiments of repeated full-benchmark reruns demonstrate the robustness of the benchmark, while further studies on real-time interaction, context-memory sensitivity, and action validity expose more challenges ahead for game agents. Together, by offering a standardized, verifiable, and reproducible evaluation framework, GameWorld lays a robust foundation for advancing research on multimodal game agents and beyond. The project page is at https://gameworld-bench.github.io.

Large models are increasingly becoming autonomous agents that interact with real-world environments and use external tools to augment their static capabilities. However, most recent progress has focused on text-only large language models, which are limited to a single modality and therefore have narrower application scenarios. On the other hand, multimodal large models, while offering stronger perceptual capabilities, remain limited to static knowledge and lack the ability to access and leverage up-to-date web information. In this paper, we propose VSearcher, turning static multimodal model into multimodal search agent capable of long-horizon, multi-turn tool use in real-world web environments, including text search, image search, and web browsing, via reinforcement learning. Specifically, we introduce Iterative Injection Data Synthesis pipeline to generate large-scale, complex multimodal QA questions, which are further filtered with comprehensive metrics to ensure high quality and sufficient difficulty. We then adopt an SFT-then-RL training pipeline to turn base multimodal models to agent capable of multi-turn tool calling in real-world web environments. Besides, we propose a multimodal search benchmark MM-SearchExam dedicated to evaluating search capabilities of multimodal search agents, which proves highly challenging for recent proprietary models. Extensive evaluations across multiple multimodal search benchmarks reveal effectiveness of our method. VSearcher achieves superior performance compared to recent multimodal search agents and even surpasses several proprietary models on multimodal web search tasks.

The emergence of tool-calling-based agent systems introduces a more evidence-driven paradigm for pathology image analysis in contrast to the coarse-grained text-image diagnostic approaches. With the recent large-scale experimental adoption of spatial transcriptomics technologies, molecularly validated pathological diagnosis is becoming increasingly open and accessible. In this work, we propose LAMMI-Pathology (LVLM-Agent System for Molecularly Informed Medical Intelligence in Pathology), a scalable agent framework for domain-specific agent tool-calling. LAMMI-Pathology adopts a tool-centric, bottom-up architecture in which customized domain-adaptive tools serve as the foundation. These tools are clustered by domain style to form component agents, which are then coordinated through a top-level planner hierarchically, avoiding excessively long context lengths that could induce task drift. Based on that, we introduce a novel trajectory construction mechanism based on Atomic Execution Nodes (AENs), which serve as reliable and composable units for building semi-simulated reasoning trajectories that capture credible agent-tool interactions. Building on this foundation, we develop a trajectory-aware fine-tuning strategy that aligns the planner's decision-making process with these multi-step reasoning trajectories, thereby enhancing inference robustness in pathology understanding and its adaptive use of the customized toolset.