Nhoodie/omni-dna-ici-dc-bootstrap

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⚠️ IMPORTANT WARNING — Model Effectiveness

These bootstrap models are part of a degeneracy chain. The ICI-DC bootstrap S1 was trained on synthetic data generated by a model (S2-coeff1.5) that itself had underfit during training. The bootstrap S2 was then fine-tuned on that degraded S1. Each generation of fine-tuning further degraded the base model's innate mutation discrimination capability (base Omni-DNA-20M achieves 0.951 AUC raw DNA; these models achieve ~0.30 AUC).

The SAD coefficient reported for the bootstrap S2 (~12.03 LR-adjusted) is a mathematical artifact of the training configuration, not an indicator of genuine training convergence.

These models are preserved for historical and reproducibility purposes only.

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Omni-DNA ICI-DC Bootstrap Checkpoint

Omni-DNA-20M fine-tuned on 8,112 bootstrap synthetic mutation pairs via ICI-DC pre-training.

Training Details

• Base model: zehui127/Omni-DNA-20M (20M params, OLMo causal LM, BPE tokenizer)
• Training data: 8,112 synthetic mutation pairs generated by SAD coeff1.5 checkpoint via ICI-DC
• Best checkpoint: Step 1250 / epoch 4.92, eval loss 1.663
• Hyperparameters: LR=5e-5, epochs=10, batch_size=16, grad_accum=2, cosine schedule

Benchmark (826 test pairs)

Axis	Metric	Score
Mutation Detection	F1	0.667
Embedding Distance	Seq AUC	0.543
Masked Prediction	Surprise Δ	−1.00
Discriminative	AUC	0.306

Related Models

• Nhoodie/omni-dna-ici-dc — Original ICI-DC checkpoint (same training, different synthetic data)
• Nhoodie/omni-dna-sad-mutation-bootstrap — This model after SAD attenuation