Datasets:
uuid stringlengths 8 8 | name stringclasses 17
values | design_set int64 1 10 | intended_toxins stringclasses 8
values | format stringclasses 2
values | length_aa int64 55 234 | sequence stringlengths 55 234 | binder_against stringclasses 4
values | Cn2_Adaptyv_result stringclasses 2
values | Cn2_Adaptyv_KD_nM float64 3.1 350 ⌀ | Cn2_Twist_result stringclasses 4
values | Cn2_Twist_KD_nM float64 1.7 2.71k ⌀ | Ts1_Adaptyv_result stringclasses 2
values | Ts1_Adaptyv_KD_nM float64 9.14 807 ⌀ | Ts1_Twist_result stringclasses 4
values | Ts1_Twist_KD_nM float64 28.1 2.05k ⌀ | AaHII_Adaptyv_result stringclasses 2
values | AaHII_Adaptyv_KD_nM float64 21 3.44k ⌀ | AaHII_Twist_result stringclasses 4
values | AaHII_Twist_KD_nM float64 1.68 29.1k ⌀ | AaHI_Adaptyv_result stringclasses 2
values | AaHI_Adaptyv_KD_nM float64 1.65 360 ⌀ | AaHI_Twist_result stringclasses 4
values | AaHI_Twist_KD_nM float64 6.58 30.6k ⌀ | LqhIII_Adaptyv_result stringclasses 2
values | LqhIII_Adaptyv_KD_nM float64 4.34 199 ⌀ | KD_note stringclasses 7
values | CLEC12A_Twist_result_run_1 stringclasses 4
values | CLEC12A_Twist_result_run_2 stringclasses 5
values | Cn2_Twist_Rmax_ratio float64 0.36 0.91 ⌀ | Ts1_Twist_Rmax_ratio float64 0.52 4.17 ⌀ | AaHII_Twist_Rmax_ratio float64 0.03 2.49 ⌀ | AaHI_Twist_Rmax_ratio float64 0.13 7.36 ⌀ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
02090d8c | Cn2-B4 | 1 | Cn2 | single domain | 118 | SVSFEEALAEALKKQGITLSEEEREILDRLNEIGDVYDKKSLNYPNDKEFKEALLEELGLSDEQKEELKDYNAGTLVIAVAAKKLGLSPEELYELIAKISGDDISARRIAKALEILLK | Cn2 | hit | 112 | hit | 48.3 | no hit | null | no hit | null | no hit | null | no hit | null | null | null | no hit | null | null | null | null | no hit | no hit | 0.723 | null | null | null |
888c8f04 | Cn2-B1 | 1 | Cn2 | single domain | 104 | MQELQDKYVEHMKKAYEAYKAKNYKESGKHFKQAIDALVERLEKLAKKFGATEAVKPYIDEIRKAGDELASAVEKGDEKKMQEAIDRIEEALGGFHEALRKVTA | Cn2 | hit | 3.1 | hit | 1.7 | no hit | null | no hit | null | no hit | null | no hit | null | null | null | no hit | null | null | null | Cn2: both KD are upper limits | no hit | no hit | 0.625 | null | null | null |
8ac202c8 | Cn2-B3 | 1 | Cn2 | single domain | 103 | SEFERALTVEGLVDYYREFAEKYGNEEAALQAIRIFERAAEVAEKALKTPGIGFPGAQEVLEAARRAIKEAKEDPIPAVRAFAEVVLPLNKEYGEQINKAEAA | Cn2 | hit | 162 | hit | 40.1 | null | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | null | no hit | no hit | 0.386 | null | null | null |
66c2cc29 | Cn2-B2 | 1 | Cn2 | single domain | 81 | SDVWSEEQQKAKDAIFEAMDTIAEKLAPDLIDKDLNDPEAIALSQEVSVAVRAALKPVVEHLEKGDYDGAAEAARAAAEAV | Cn2 | hit | 5.57 | hit | 3.43 | no hit | null | no hit | null | no hit | null | no hit | null | null | null | no hit | null | null | null | null | no hit | no hit | 0.571 | null | null | null |
05efdf6e | null | 1 | Cn2 | single domain | 84 | SRKQHIDESLSKEEIVKELVEGSELVLKLAEEMRANGVDPEVIADFLEQALRFIEEVMKKFNIDDPEVKEQLERLREAIAEAKA | null | no hit | null | weak or ambiguous | 2,710 | null | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | null | hit | hit | 0.908 | null | null | null |
c23660b4 | null | 1 | Cn2 | single domain | 101 | SAQLERALKAVEDFAKKYGISKEQLEKAKEIVEEVFREKIPQSKIRALLETMYKNTQSPFIGELLKKYGPGQEYEAFAELVAYTLKKDPELTVDEILSTVR | null | no hit | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | null | no hit | no hit | null | null | null | null |
e9a01963 | null | 1 | Cn2 | single domain | 94 | MMKLSDEQIEKIRRYLAGEISIDELSPEEVVYLADYLITLSKGEIEPPFGLTEDQIRKMLEEVARKAEELAKEGKLSESTARRIVERVEEELKK | null | no hit | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | null | no hit | no hit | null | null | null | null |
569171b8 | null | 1 | Cn2 | single domain | 78 | PDEIVEILEELQKSSNPNTVLLAKILLEAYKEFKETGEDFGKILLEKTKNLPSTEKVSIPPEDLKKLQEIYETLLKES | null | no hit | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | null | no hit | near background | null | null | null | null |
ca06e722 | null | 1 | Cn2 | single domain | 84 | SMEELEQTKKEIEAKVLELSKDPSKENIEKFKEWLEGLTKRFSVDELGELFLHLSKELQKHITDPKIVQEIMEHAAKLYLEKLK | null | no hit | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | null | no hit | no hit | null | null | null | null |
5f5b71ad | Cn2-B7 | 1 | Cn2 | single domain | 74 | SEERERLLEAAEYALKHSTDPLVLKIAEAVKAGDLEKLKEIAEEVYKRNLARPGADEELVKKDVEEGLKQFEEA | Cn2 | hit | 350 | hit | 580 | null | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | Cn2: Twist Bioscience's KD is approximate | no hit | no hit | 0.817 | null | null | null |
8f127bdf | null | 1 | Cn2 | single domain | 55 | SKAMRDRFIQRLEKEAEVLEESDPEFAEKLREIARRIRELDPSYEEARELAKNSV | null | no hit | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | null | no hit | no hit | null | null | null | null |
3369ca93 | null | 1 | Cn2 | single domain | 98 | GPVLTLDAHSDGTVTITSSRSGKTVTLPADDPRIPQVAADMIIEDQATTVIYKVDGKTVLEVTFPSPEIARKYAELIKEKGGVSASEVRSLGGTMKVY | null | no hit | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | null | no hit | no hit | null | null | null | null |
85342f05 | null | 2 | Ts1 | single domain | 88 | ELSDEEWRKLAEITIELLRKKLAEETDPEVQAALQEVIDLLERFLAGELSREELRARITALMERASPESQAVLSEIGDEAFRTFQKLY | null | null | null | no hit | null | no hit | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | null | no hit | no hit | null | null | null | null |
173c84c2 | null | 2 | Ts1 | single domain | 100 | SELDRIVSLISEAVDLSIKEKLAIEKGDYELAQKYAEKQQVVNRELEKLLSPETLARLQALWDEWEKEVEEKKYSEEEIEERKKTLIEKMREVVAEELAR | null | null | null | no hit | null | hit | 17.2 | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | null | no hit | no hit | null | null | null | null |
01f0df6e | null | 2 | Ts1 | single domain | 88 | SVEQQKERLIEWLVEKMGLSKEKAEELANQIEQISKDLEERKKGKSDEEILELTNQANKKIYDLLKSYGITSDQVNEQADESLAKKRA | null | null | null | no hit | null | no hit | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | null | no hit | no hit | null | null | null | null |
a31d8156 | null | 2 | Ts1 | single domain | 104 | MSVEERIEKLAKELASLSPEEVIAILQTDLDNLRKLLDEAREKGVATPEQIKALEDLIGKVEEALRILKENPDLSKEERYEIMKEVLEFAEKNRKALLNTYDKL | null | null | null | no hit | null | no hit | null | weak or ambiguous | 110 | null | null | no hit | null | null | null | no hit | null | null | null | null | no hit | no hit | null | 0.522 | null | null |
c29a9b88 | null | 2 | Ts1 | single domain | 62 | PSKKDMEEALEAARKGDVEKAAEILYKAELKDNSDVELTEEQKALLKEMSRETAEILYELAK | null | null | null | no hit | null | no hit | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | null | no hit | no hit | null | null | null | null |
82abc3c1 | null | 2 | Ts1 | single domain | 100 | SEILEEARRVADRIVALAAAHPELTRKLLRGELDNPDDPAAQELRRLSARLRELLDKLSPEEQIEILTALYDALGEVLPDEKELIERLKEENVAFINSQA | null | null | null | no hit | null | no hit | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | null | no hit | no hit | null | null | null | null |
56dd795b | null | 2 | Ts1 | single domain | 120 | SEFDELLKRADELVEKIKNTDNPEEQIRLIKELAEVMERFIKLVLENPSEERFKAVRDLQVKFREVLRYAVKKLSDEQFVELIVELGKDAKYIDKEALREFLRLLGASDETIEKVLKALE | null | null | null | no hit | null | no hit | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | null | no hit | no hit | null | null | null | null |
abcdee20 | null | 2 | Ts1 | single domain | 104 | MLTKEEIINIAEEIKDLVMNEVPAVLNDKSLSDEEKQKRLNEINDKMYELFEKLKDYKELYAKFKEIFDQIGKLLVQSTDFSDPALWAEIEKLLDEMVQLAKDY | null | null | null | no hit | null | no hit | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | null | no hit | no hit | null | null | null | null |
cea7b270 | null | 2 | Ts1 | single domain | 108 | SDDPVERLYKALEEHGYHDLLEKLRYFGKQFTKYVEQGKIDEFIKEFKPVLEEIIEAGKENGFLDEVVAFLELLVRNLESYVKEKNDEEMKPLLDLFRELLERAKSLL | null | null | null | no hit | null | no hit | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | null | no hit | no hit | null | null | null | null |
5545ab00 | null | 2 | Ts1 | single domain | 99 | GRVVEVFYDGNGKVTVKDLATGREVVGDLNDPESAKAAADLILEAKPAEVIATDKYGNRGVLGPEGAEHLARAIIAKGEGKLDEATYHGNRANALARPA | null | null | null | no hit | null | no hit | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | null | no hit | no hit | null | null | null | null |
b46280d0 | null | 2 | Ts1 | single domain | 81 | PNLDSEEVIQANKRLKEAIEKLLKENPDISYEELKEFMIKKALELAKELGIETSEEDIRLAAEKYIKELKKEEEARQAALS | null | null | null | no hit | null | no hit | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | null | no hit | near background | null | null | null | null |
8c613690 | null | 2 | Ts1 | single domain | 82 | SENVKILKEFFKPYLEGELSIRYLLSLKPEDIIANIPGFKPSEEEKKLFIEWFTKFRAEHPNPSLEEFRKWVEEFLKKLEDL | null | null | null | no hit | null | no hit | null | weak or ambiguous | 2,050 | null | null | no hit | null | null | null | no hit | null | null | null | null | no hit | no hit | null | 1.165 | null | null |
bdeffba4 | null | 3 | AaH II | single domain | 99 | SPADMRERASKETDPDLRLAGLLTAEAIEEINRLTDELVEKVKAGEISAEEAIARLEELKERLIAEARERLTDPTNIESVENAINAQVDEAKKEIRAAA | null | null | null | no hit | null | null | null | no hit | null | no hit | null | no hit | null | null | null | no hit | null | null | null | null | no hit | no hit | null | null | null | null |
a199ee01 | AaHII-B4 | 3 | AaH II | single domain | 109 | SNSERLSNLIDELIEQKNYEDLAFIAETFGELLAEEARKRGEDEIAEKVRELGKKAAEAALKGDYDSFFKYVSEAAKLAATIYESDEEAEKEFEKIHGRVLEKYEESKK | AaH II | no hit | null | no hit | null | hit | 9.14 | hit | 28.1 | hit | 21 | hit | 6.31 | null | null | no hit | null | null | null | Ts1: Adaptyv Bio's KD is an upper limit | no hit | no hit | null | 4.173 | 0.541 | null |
6278a864 | null | 3 | AaH II | single domain | 84 | SVDEILAELREELLKILNEKSTDRTVEAVKRTIEELNLDPELVAQLALASAKADASEEGSPEWEKYVAKSRELVEQIRKKYGPL | null | null | null | no hit | null | null | null | no hit | null | no hit | null | no hit | null | null | null | no hit | null | null | null | null | no hit | no hit | null | null | null | null |
bf9f87d6 | null | 3 | AaH II | single domain | 86 | SHMDALKEQEEKEIERIKQAILDMLASDTAEEDLAHMKEILRKLYEEQGLEEAKKAIEALEAGDYEEAARYILKISKILKAKEEAQ | null | null | null | no hit | null | null | null | no hit | null | no hit | null | no hit | null | null | null | no hit | null | null | null | null | no hit | no hit | null | null | null | null |
70e95c3a | null | 3 | AaH II | single domain | 88 | SSMDAEKALEDRIAELRAQGKTGMASMLQSIKDYLKKEGWTIVEFRQLSDDHFEIVAENKKGEKMTVTISVDPDLGVVNEVSGISPEP | null | null | null | no hit | null | null | null | no hit | null | no hit | null | no hit | null | null | null | no hit | null | null | null | null | no hit | no hit | null | null | null | null |
bbe37cf8 | null | 3 | AaH II | single domain | 95 | KLYSIHEIADIAGISSEEALKRNIEVSRAVTAHLDEVAARLRAAGYSDEQIAAIVEAARVAASEAMLAGLKAGKSTEEITAAALAAVEEAVRAAV | null | null | null | no hit | null | null | null | no hit | null | hit | 1,290 | hit | 145 | null | null | no hit | null | null | null | null | no hit | no hit | null | null | 0.579 | null |
47dd0a8a | null | 3 | AaH II | single domain | 71 | KVYVTPEGKKQAEEVKAIIDEGEAAGLTPREILARLGEKFNVPWLKELDDEEAEETLAKIRQSVDDALAAP | null | null | null | no hit | null | null | null | no hit | null | hit | 3,440 | hit | 65 | null | null | no hit | null | null | null | AaH II: Adaptyv Bio's KD is approximate | no hit | no hit | null | null | 0.558 | null |
1296b21d | null | 3 | AaH II | single domain | 85 | SPVDLALKTLEEVKEQVKEADISQKVKDSLLKNINRAIEYIKENKDTLSNQQLAEILKSLAIILEDAGLNDAAEKLRKTAEKILA | null | null | null | no hit | null | null | null | no hit | null | hit | 3,380 | hit | 1,850 | null | null | no hit | null | null | null | null | no hit | no hit | null | null | 0.696 | null |
a8a3f1f9 | null | 3 | AaH II | single domain | 71 | SAADAIREALSTRLGMNPTDATLEAIVTEGARAVVDGLLEEARKRKQVISDEAEASLREAAELAEATLASL | null | null | null | no hit | null | null | null | no hit | null | no hit | null | no hit | null | null | null | no hit | null | null | null | null | no hit | no hit | null | null | null | null |
31723df8 | null | 3 | AaH II | single domain | 102 | SNAPLSPEEKALLEKQKKFYEENKDEVIELAREGMRLQGFSDEEIEERIKKIEEYVKKGDYRPLITSALAGAIALGDWETVEKLKSLLSPAEQKQVDYFLSK | null | null | null | no hit | null | null | null | no hit | null | no hit | null | hit | 2,730 | null | null | no hit | null | null | null | null | no hit | no hit | null | null | 1.491 | null |
d2a254ba | AaHII-B1 | 3 | AaH II | single domain | 95 | ATPEAIERSLKLADEFVEIAKTLPVEDQAVLAVASEISAKRAEPGSPARIADQYVADKLREWVLSQGKQDVLDRVRALPEEEVIARAQAIVDSLD | AaH II | no hit | null | no hit | null | no hit | null | no hit | null | hit | 78.1 | hit | 1.68 | null | null | no hit | null | null | null | null | no hit | no hit | null | null | 0.562 | null |
4fcc0f88 | null | 3 | AaH II | single domain | 75 | MLPSVDELLQQIVDAIKAGDFDKAVELLEEAQKQYSDKQLDELARKFQELIDSGEISKEQAEAFNKAWTAYIESL | null | null | null | no hit | null | null | null | no hit | null | no hit | null | hit | 2,230 | null | null | hit | 6.58 | null | null | null | no hit | no hit | null | null | 0.549 | 1 |
1578f84e | null | 4 | AaH I | single domain | 72 | SSEAEARAQEIIDWMDKHPEEVELSDADSYEQGAAAAEKVVATSTDPELIEKAKVDAEVGRMVAAWIREKLG | null | null | null | no hit | null | null | null | no hit | null | null | null | no hit | null | no hit | null | no hit | null | null | null | null | no hit | near background | null | null | null | null |
6da28c32 | null | 4 | AaH I | single domain | 100 | SKMEEVKKRIADLLARAIDYLNSGDVAGARAKLAELAEIFREDPELARKAADELIDSTDMPEEIKAKLREMMARIEAGDIDGALAKLEEMLAVASTYVLP | null | null | null | no hit | null | null | null | no hit | null | null | null | no hit | null | no hit | null | no hit | null | null | null | null | no hit | no hit | null | null | null | null |
0c86c52b | null | 4 | AaH I | single domain | 72 | SALQRALENIKRLKEWAEEHFKRTGVRFEVLDEEGELAAVHGDQVTLAVRVRIDGEVRTVYVSSDSTRDPLP | null | null | null | not assessable (capture <50 RU) | null | null | null | not assessable (capture <50 RU) | null | null | null | not assessable (capture <50 RU) | null | no hit | null | not assessable (capture <50 RU) | null | null | null | null | not assessable (capture <50 RU) | not assessable (capture <50 RU) | null | null | null | null |
917b6d05 | null | 4 | AaH I | single domain | 71 | MQELIDNVKKSIDALEEYVSNGGKLTPSQIKALQEALKHLEELLKKTKDPALQKQIQENIERIRKLLEKAS | null | null | null | no hit | null | null | null | no hit | null | null | null | no hit | null | hit | 360 | no hit | null | null | null | AaH I: Adaptyv Bio's KD is approximate | no hit | no hit | null | null | null | null |
30fc4a66 | AaHI-B1 | 4 | AaH I | single domain | 75 | SGELTRAAEDAYAAGDNKAYALALKRQVELALTSAGLHDEARKYVGLLEEAAKNNDLEKAVKTTQEAAEVLRRSE | AaH I | null | null | no hit | null | null | null | no hit | null | null | null | no hit | null | hit | 6.46 | hit | 26.2 | null | null | AaH I: Adaptyv Bio's KD is approximate | no hit | no hit | null | null | null | 0.618 |
23bf54fe | null | 4 | AaH I | single domain | 96 | MTKEELLERIREAKRLIQKAAPYLPPLLVTSALAELDRVEKFLEDMIAAGKEEEGISLAWESLREIVQAVIDHLRRNFPNDPEAQKIIKELEELLK | null | null | null | no hit | null | null | null | no hit | null | null | null | no hit | null | no hit | null | no hit | null | null | null | null | no hit | no hit | null | null | null | null |
99e5450e | null | 4 | AaH I | single domain | 83 | SREQQIETTKRLEDALSKLPEALQKKIEDDINARLATAKSLEEKYQAVIDVLQKYIAESTDPAVKAALQEALKAVQDFYNSLK | null | null | null | no hit | null | null | null | no hit | null | null | null | no hit | null | no hit | null | no hit | null | null | null | null | no hit | no hit | null | null | null | null |
110493ed | null | 4 | AaH I | single domain | 86 | SEEFKENAKKAAEWALKQADTVEHAARYGSDEEALRVAEEIAQQAGKDILDIFRKEAERHGPRVGALALADKLREAAKQILESGGL | null | null | null | weak or ambiguous | 1,520 | null | null | no hit | null | null | null | no hit | null | no hit | null | no hit | null | null | null | null | no hit | no hit | 0.61 | null | null | null |
22359df4 | null | 4 | AaH I | single domain | 96 | GPLSEEELKEVHTELNRLLEEIYDLVKQVKAGKLDPNSEEVKNKIEELTKRAEEVLARFEKAVEDYGKGVMSPEERERIVETIREYIKKLLDEIKK | null | null | null | no hit | null | null | null | no hit | null | null | null | no hit | null | no hit | null | no hit | null | null | null | null | weak or ambiguous | no hit | null | null | null | null |
03131527 | AaHI-B2 | 4 | AaH I | single domain | 93 | SMEEKLKELLDEAGKYAEKGIQAVENGDYDTAREYFKKAAEYLEKAAELVTDPQDREIILKEAEKFRELAESEDPQDLEDYLNKLKDYHKKQS | AaH I | null | null | no hit | null | null | null | no hit | null | null | null | no hit | null | hit | 62.9 | hit | 57.9 | null | null | AaH I: Adaptyv Bio's KD is approximate | no hit | no hit | null | null | null | 0.789 |
97559b03 | null | 4 | AaH I | single domain | 105 | SSAEQARLAQLLAQYDEALKRLKEAIERAKEVVPDAGKKLKGTGRGPEQISEELEEKLPKDVLEELKKALEDVDSIGGELGDTAPLELRQQLVAASQKFAKSLTE | null | null | null | no hit | null | null | null | no hit | null | null | null | no hit | null | no hit | null | weak or ambiguous | 27 | null | null | null | no hit | no hit | null | null | null | 0.134 |
4412a3c3 | null | 4 | AaH I | single domain | 100 | SALEEMKQMASTIPSDASSLEVVAKLREIVNTLMDKYKIPADVAAEINALMAQFEAQTKKLAEAIEKNSPQEVIDQLAKEANALATQMMKKLVDALKAAE | null | null | null | no hit | null | null | null | no hit | null | null | null | no hit | null | no hit | null | no hit | null | null | null | null | no hit | no hit | null | null | null | null |
b7640b51 | null | 5 | LqhIII | single domain | 84 | PSKEARELAEEALELAKKSKNPAQRTTLEILAEAALQAKTDEEIEILREAVEKAKEVKNFDEAYELLTETGEKLKAIVDERLDK | null | null | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | no hit | null | no hit | null | null | no hit | no hit | null | null | null | null |
37b43daf | null | 5 | LqhIII | single domain | 79 | SMEDRIEAEAERILAAMEGKSPEEQAQVISDRAPALEEELGPIAAAEVAVRVLERLAARDPIWQPLLDSAREELARLKK | null | null | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | no hit | null | no hit | null | null | no hit | no hit | null | null | null | null |
dceea244 | LqhIII-B1 | 5 | LqhIII | single domain | 99 | SAGEELAKLIQDSDVEGIYKLLQEHGLTAESSAEDVKKATGASDHVARSSVIMAMAYAAGVSLEKVEDFSLSHPEKFAEVAQKVLEGKMSPAEFKKALE | LqhIII | null | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | no hit | null | hit | 4.34 | null | no hit | no hit | null | null | null | null |
b033f20c | null | 5 | LqhIII | single domain | 77 | MKRFGDIVARVASLGRAEEVELVAEAAVRLGYLPESFTFEEAADVLVDPEELVREMRRLAAERGLEISQEALDAVLA | null | null | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | no hit | null | no hit | null | null | no hit | no hit | null | null | null | null |
88ef5fe9 | null | 5 | LqhIII | single domain | 85 | MSPAERQRELDERARELADATFSPDPEVRRRAARELARLVREHGDELSPETLRYVAERAEALTTDPDPEVRNAAAIAGEAAEAAL | null | null | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | no hit | null | no hit | null | null | no hit | no hit | null | null | null | null |
dbb87a88 | LqhIII-B2 | 5 | LqhIII | single domain | 78 | SMAEDEKIYKDIKDTLLNLGFSEEEAEKLAEILLEMIKQGVIGYDGSSKPEEAKELPEDVREQQRKILEGILKEAEKK | LqhIII | null | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | no hit | null | hit | 40.6 | null | no hit | no hit | null | null | null | null |
24baf4bf | null | 5 | LqhIII | single domain | 99 | MSPVKQEAIELAREIAEKSKDPAVIEAAERLREFVEETDNPSAHVIALEALKAASKIKDPKVQTAVLEEGLRLARAADEGASKEELERLSAALQAAVEA | null | null | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | no hit | null | no hit | null | null | no hit | no hit | null | null | null | null |
4d787f86 | null | 5 | LqhIII | single domain | 91 | SQREAAIALLRKAVADVEPSAASSPDNAAFVEILREAIRLLEEEGASLDEVRQKIAELMKKRGLEAGLSEEEATEIAEKTADTIRQAMLAA | null | null | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | no hit | null | no hit | null | null | no hit | no hit | null | null | null | null |
6fbd27ee | null | 5 | LqhIII | single domain | 78 | SAVDKLIEEQLEIARKEFETLMATVKPDPDALYETIFSGFKADVAKLEDEELKKYMIETFSKELQKLRDEAKKKYGFP | null | null | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | no hit | null | no hit | null | null | no hit | no hit | null | null | null | null |
21c4722c | null | 5 | LqhIII | single domain | 87 | SELAAEVERERAEIDKITNKEKLKQLGESYIEEAERLKGSTDPEEQRRYLRALSLALIIAAKVTGKDIVPQSDEELLEIAREALKKL | null | null | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | no hit | null | no hit | null | null | no hit | no hit | null | null | null | null |
142cb24a | null | 5 | LqhIII | single domain | 76 | SRDEEVLERMKKAYEEANGDKVEAARRIGELLEEEYGVKATMTPDGTGFLLSGEPEKLAKARKVLEELGKWIIEQQ | null | null | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | no hit | null | no hit | null | null | no hit | no hit | null | null | null | null |
a01ae210 | null | 5 | LqhIII | single domain | 81 | SKEIEELKKIKEILQKIVEDARANGYSLDEILEKIKEELPEDVYEALMKAFERAGVKTREEALAFLEGVIKSIEKSIEFLS | null | null | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | no hit | null | no hit | null | null | no hit | no hit | null | null | null | null |
ec765866 | null | 6 | Cn2; Ts1 | single domain | 110 | MEEEAERGAQLTVENILDPSKMTVEDLRQTLDRALAKAPAYLATLSAEELRELKRWIEVQTRATLRALDEAEAASTDPNVKARLAEAKRLIEEASRQLLAMIDEELARKE | null | no hit | null | no hit | null | no hit | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | null | no hit | no hit | null | null | null | null |
a6a68a39 | null | 6 | Cn2; Ts1 | single domain | 74 | SEEEKKIIDAANKLINSKNPKVQELTRKLIEALQNEDFEEARKILDEIFKVDPSLKPYEKYLRKLIDEAEERSK | null | no hit | null | no hit | null | no hit | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | null | no hit | no hit | null | null | null | null |
4efbc623 | null | 6 | Cn2; Ts1 | single domain | 97 | SIEEKLKKVVEEGRKVMAQLEASGPAVQALIDKLEELVEKIYRDNPDATREERVKRILEESRKLIDEADITPEQKALLYRLLDLFEEYVKLEKELSK | null | no hit | null | no hit | null | no hit | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | null | no hit | no hit | null | null | null | null |
346a7f1f | null | 6 | Cn2; Ts1 | single domain | 85 | SLVEEAARLIKEATRLLLRYHGETDEAAIEEFADSVAKGFLNRVEELEEIPSPEEVYEKAKAVSTDEVARLGAEAAELLIEAKKQ | null | no hit | null | not assessable (capture <50 RU) | null | no hit | null | not assessable (capture <50 RU) | null | null | null | not assessable (capture <50 RU) | null | null | null | not assessable (capture <50 RU) | null | null | null | null | not assessable (capture <50 RU) | not assessable (capture <50 RU) | null | null | null | null |
e32555c5 | null | 6 | Cn2; Ts1 | single domain | 110 | SDEKVYQLQAEALELTAELARERGMPQEVVDGLLEAAEMARQGIEPDQSFEQALLAAVEPLLEPVQETLILAKRENLAKEEAVELALKRSGGNELVARITALALEIQDLE | null | no hit | null | hit | 750 | no hit | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | Cn2: Twist Bioscience's KD is approximate | no hit | no hit | 0.625 | null | null | null |
268861a2 | null | 6 | Cn2; Ts1 | single domain | 74 | SMLEEKQYQAAQLLVNSANPEVRALTKELKKALLSEDFEKAREILEEILQVDPSLEPYRPYLLKLIEDAKKRSE | null | no hit | null | no hit | null | no hit | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | null | no hit | no hit | null | null | null | null |
ae04db8a | null | 6 | Cn2; Ts1 | single domain | 110 | SEEERKRAVIEVLEMLAEYLERKGYPQEDVEALRELAELAREGKSPSQEFLTELYKRLSDILDPIGELLTEAHKEGLSVEELKKRVLEVFGGDEILAEAVGLLYRVSGAE | null | no hit | null | no hit | null | no hit | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | null | no hit | no hit | null | null | null | null |
0f463bed | null | 6 | Cn2; Ts1 | single domain | 94 | MSARQLFEEGLRAAQAGDDEKALALFREAAAQAPISPEGAALVEEVRAAAATGDEKALNEAASRASEAFSTEKDEDARIGALAALGVVVLSAKL | null | no hit | null | no hit | null | no hit | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | null | no hit | no hit | null | null | null | null |
eade0bd3 | null | 6 | Cn2; Ts1 | single domain | 72 | SIENKDTLLRKLADPAELDRLIAQVREQIAKETDPKRRAHLEQVLAILEKARAGELTPEQAVAEIDRLDSTV | null | no hit | null | no hit | null | no hit | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | null | no hit | no hit | null | null | null | null |
d1ce49a2 | null | 6 | Cn2; Ts1 | single domain | 75 | SVLERAKKELEEIRAQLEKMGYLKDPVIKANLDRVEAELEKLSPKEREIVVQSLRDFLEMLKKYGKELIEKLKSR | null | no hit | null | not assessable (capture <50 RU) | null | no hit | null | not assessable (capture <50 RU) | null | null | null | not assessable (capture <50 RU) | null | null | null | not assessable (capture <50 RU) | null | null | null | null | not assessable (capture <50 RU) | not assessable (capture <50 RU) | null | null | null | null |
a6efe904 | null | 6 | Cn2; Ts1 | single domain | 74 | SEERKKMYEAAEKLINSKNPKVQELTKKLIEALLNEDFETARKILDEIFKVDPSLKPYRKYLEKLIDEAEERSK | null | no hit | null | no hit | null | no hit | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | null | no hit | no hit | null | null | null | null |
925ee271 | null | 6 | Cn2; Ts1 | single domain | 85 | SLVEEAAELLREATKLLLRHKGETDEAEIELEAESVQKGFLNRVDSLDEIPSPEEVYQKALSVSTEEVAELAARAAELLRQAKAS | null | hit | null | not assessable (capture <50 RU) | null | no hit | null | not assessable (capture <50 RU) | null | null | null | not assessable (capture <50 RU) | null | null | null | not assessable (capture <50 RU) | null | null | null | null | not assessable (capture <50 RU) | not assessable (capture <50 RU) | null | null | null | null |
79a1814e | null | 6 | Cn2; Ts1 | single domain | 72 | AISDEQLLLEYLSDPEKLDELIAQVEAQIARETDPGKRAHLEKVLAILRQTRAGKLTPQQALEAILALDVST | null | no hit | null | no hit | null | no hit | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | null | no hit | no hit | null | null | null | null |
2afea962 | null | 6 | Cn2; Ts1 | single domain | 72 | SISEQDTLLKMLADPAKLAELIAQVRAQIAQETDPARKAHLEKVLAILERTAAGELSPEQAVEEINSLDVST | null | no hit | null | no hit | null | no hit | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | null | no hit | no hit | null | null | null | null |
a8411894 | null | 6 | Cn2; Ts1 | single domain | 83 | MEEEIRKLNEKVREADRGIEESYQRMKELKAEAEKETDPEKIEQIVREAVRIHDRALDLAYEVTGSEEEAVKWLHEKYPEFGK | null | no hit | null | no hit | null | no hit | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | null | no hit | no hit | null | null | null | null |
9d008884 | Cn2-B5 | 6 | Cn2; Ts1 | single domain | 110 | TDAKVYALQAEALRLLAELARSEGMPQSVVDGLLEAARLAEQGIEPPQSFERELLAAVEPLIEPVQDALIEGKKNKLSKEETVKLALERSGGNELQARITALALEIQDLE | Cn2 | hit | 88.6 | hit | 49.8 | no hit | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | null | no hit | no hit | 0.441 | null | null | null |
2a608b59 | null | 6 | Cn2; Ts1 | single domain | 75 | SAMEQDRAELARLIAEAERLGLLADPRIRAAFERVEATWESLDDETRRLVLRSIREFLERYKQEGDAYLERLFSL | null | no hit | null | no hit | null | no hit | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | null | no hit | no hit | null | null | null | null |
9a8cdc7a | null | 6 | Cn2; Ts1 | single domain | 110 | MDELEKRGLAVLEKILLGDNPPSIEETQILLNKVKNKLDEYLSTLSIEELKELIERNKRYKEGLKELKEKVLSKIKDPERKAHVEKIIDLYLETLDYIIKKAEERIKELE | null | hit | null | hit | 772 | no hit | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | Cn2: Twist Bioscience's KD is approximate | no hit | no hit | 0.531 | null | null | null |
f7afd975 | null | 6 | Cn2; Ts1 | single domain | 110 | MDEQLKRGIEILKKELLGPNPITVEEMQSLIDRVLSKLDEYLSKLSIEELQDLIKTLEKYNELLEELKKEVLAQISDEEKKKKVTEIIDLMLDANKQIIEKAKKKIEELK | null | no hit | null | no hit | null | no hit | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | null | no hit | no hit | null | null | null | null |
47d04ba8 | null | 6 | Cn2; Ts1 | single domain | 110 | SSLELSDEEIEENRKILLDALLAAGVDKETAEKIVEEIIKLVKSNKHISFDDIINIFIKHGVTEEQFRKFLELLRDRYLESTQVSPEELKLIDENVEDVINRYREKLAKL | null | no hit | null | no hit | null | no hit | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | null | no hit | no hit | null | null | null | null |
367f7a60 | null | 6 | Cn2; Ts1 | single domain | 110 | MDSAALQALFQEFLADPAYWAQLEKELRAIMTKAGMSEEDIDKFLAVLRDPSPSEEQLLEMEAILNKLSDEARKQILGALLDGLIAYARSQGRDDVAAWLEEQKKDILGV | null | no hit | null | no hit | null | no hit | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | null | no hit | no hit | null | null | null | null |
b39bbbd3 | null | 6 | Cn2; Ts1 | single domain | 75 | SAKQEALEALDELEETLKKAGADKVPGVQEALERARASIPSLSDKEALVQAESLRETAEQVKKFGVAYVERLKAK | null | no hit | null | no hit | null | no hit | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | null | no hit | no hit | null | null | null | null |
fc655cd5 | null | 6 | Cn2; Ts1 | single domain | 87 | SYVPSDEEITKNVVEYLDDLLSLGYSFEEIAQRLRDVLEKEKETVDLSEEDINKLLELIDEIGKSKTKEEALEKLVELAKFVIDTLG | null | no hit | null | weak or ambiguous | 879 | no hit | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | null | no hit | weak or ambiguous | 0.356 | null | null | null |
8382cd8f | null | 6 | Cn2; Ts1 | single domain | 87 | SPVPSDEELRAQATEFVDEMLSLGFSLAEIGEYLGKALDRDLSVTSVPAELAERLRALVEQIGAAKSREEAVALLTEAGRLVLDHWS | null | no hit | null | hit | 874 | no hit | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | null | no hit | near background | 0.372 | null | null | null |
b6d46ba0 | Cn2-B6 | 6 | Cn2; Ts1 | single domain | 97 | SLEEKLKEVVEEGRRVQKEIENSGQKAIDLMNKLEELVEKIYRDNPDATREERIKRILTESRKLIDEADISPEVKALFRRLLDLFEEYVKLENELEK | Cn2 | hit | 63.3 | hit | 53.8 | no hit | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | null | no hit | no hit | 0.406 | null | null | null |
3f0f990a | null | 6 | Cn2; Ts1 | single domain | 85 | SLVEKAAELLREATKLALRYHGETDEDLIEEEAKSVQKGFLNHVDSLEEIPSPEEVYQKALSVTTEEVAELAKEAAELLIKAKES | null | hit | 84 | not assessable (capture <50 RU) | null | no hit | null | not assessable (capture <50 RU) | null | null | null | not assessable (capture <50 RU) | null | null | null | not assessable (capture <50 RU) | null | null | null | null | not assessable (capture <50 RU) | not assessable (capture <50 RU) | null | null | null | null |
c4bf2b3e | null | 6 | Cn2; Ts1 | single domain | 83 | SLEDLQAFMEKVNKIVEEFKKILERLREVQARYDAGMPEEEVLAEVRKLQIEMDKVLDEAVKLFGSEKKALEFFRKNFPEFFP | null | no hit | null | no hit | null | no hit | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | null | no hit | near background | null | null | null | null |
a9ff4905 | null | 6 | Cn2; Ts1 | single domain | 98 | GAMAELARQLAGEDSPETRRVNEALRKVLLGEATPEEAKLVIDYAEKARPTADPALRQVLDYFIALAKKVLGIEAEEPELSPRARKIFDEAVANAKAA | null | no hit | null | no hit | null | no hit | null | no hit | null | null | null | weak or ambiguous | 31.9 | null | null | no hit | null | null | null | null | no hit | no hit | null | null | 0.03 | null |
82c02c9d | null | 6 | Cn2; Ts1 | single domain | 110 | SPLVDNPPKAIAANPEVTAALKALMAAVEARAPYGSREYIDLLIEALVLAVAKADPSVTEEQKAQAIAKGRAVLTTLEEAEDAAETLLSYLSKKPVETQVAALNAAAEAV | null | no hit | null | no hit | null | no hit | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | null | no hit | no hit | null | null | null | null |
27764014 | null | 6 | Cn2; Ts1 | single domain | 98 | MIDTTPVPLRKGPDPAVSLRANELLEKLLRGEATPEEVQNLLAILDSLPTDMDPALREVVDYLKALARKKLGEEVEFPELSPRAQRLLDEIKARVEAR | null | no hit | null | no hit | null | no hit | null | no hit | null | null | null | no hit | null | null | null | no hit | null | null | null | null | no hit | no hit | null | null | null | null |
cf8652bc | null | 7 | AaH II; AaH I; LqhIII | single domain | 107 | NELVQLELEAIKLSKKLYENGIENTPQEEVDRFIAIQNKIADLIESLINTNSVEEVVKKLSEFIEEVANHYKSQTDDPELIKEIEEAKKENIAKLKSLIEEYRKSQE | null | null | null | no hit | null | null | null | no hit | null | no hit | null | no hit | null | hit | 260 | hit | 134 | no hit | null | AaH I: Adaptyv Bio's KD is approximate | no hit | near background | null | null | null | 0.213 |
9cad7527 | AaHI-B4 | 7 | AaH II; AaH I; LqhIII | single domain | 107 | NELVQLEIEAIELSKKLYENGIENTPQEEIDRFIELQNQIADMIEKLINTNSVEEAVKILSEYINQVADYYKSQTDDPELIKEIEEAKERNIKELKKLIEKYLESKK | AaH I | null | null | no hit | null | null | null | no hit | null | no hit | null | no hit | null | hit | 89.8 | hit | 182 | no hit | null | AaH I: Adaptyv Bio's KD is approximate | no hit | no hit | null | null | null | 0.572 |
e9b98778 | null | 7 | AaH II; AaH I; LqhIII | single domain | 107 | NELVQMELEAIKLSEKLYKLGIENVPKEDVERFIELQNKIADYIEKLILENSVEEAVEELSKFIEDVTNAYIASTDDPELIKELEEAKEFNIQRLEKLIKEYRASLK | null | null | null | no hit | null | null | null | no hit | null | no hit | null | no hit | null | no hit | null | no hit | null | no hit | null | null | no hit | no hit | null | null | null | null |
6e170f78 | null | 7 | AaH II; AaH I; LqhIII | single domain | 74 | YSDETVKSQKEAIERVANDPELARQVLDSAIANNAPEEGIKVLQEVADLAEAGRAEEAKRLLIDSLSEDLQKKI | null | null | null | no hit | null | null | null | no hit | null | no hit | null | no hit | null | no hit | null | no hit | null | no hit | null | null | no hit | no hit | null | null | null | null |
52a91175 | null | 7 | AaH II; AaH I; LqhIII | single domain | 110 | MEELRKEASERGNAALQAYKEALSLADIPEELVQEIEDALLQMSKHLEAGDYEGALEELKKVIELLREAARLAEAQGAHDAAAKLREAAKELEKVMELIRELQALEKAAS | null | null | null | no hit | null | null | null | no hit | null | no hit | null | no hit | null | no hit | null | no hit | null | no hit | null | null | no hit | no hit | null | null | null | null |
3d3dff1a | null | 7 | AaH II; AaH I; LqhIII | single domain | 110 | MEELRKEASEKGNEALKNLQKALELADIPEELVNKIRQELLAMSRHLEAGDYDGAIEELNKVIELLKEMAKIAESQGKFEAAKKLEEAIENLEKVKELIEELKRLEEQAA | null | null | null | no hit | null | null | null | no hit | null | no hit | null | no hit | null | no hit | null | no hit | null | no hit | null | null | no hit | no hit | null | null | null | null |
fe18e4b2 | null | 7 | AaH II; AaH I; LqhIII | single domain | 77 | SEDEQLYKELLEAVKKAIKERSKEEVAETVEDQLRGLGYDEEAEEVRKKILEAKSDEEAAEIAAEAYMKMIKELERQ | null | null | null | no hit | null | null | null | no hit | null | no hit | null | no hit | null | no hit | null | no hit | null | no hit | null | null | no hit | near background | null | null | null | null |
96ee6417 | AaHII-B3 | 7 | AaH II; AaH I; LqhIII | single domain | 74 | SAKEQAELVKKVLEEAKKDPSILEEALKTLKENKASEESIKKVEEMLEAIKAKDYAKYEEIFLSNLEEPVKEAL | AaH II | no hit | null | no hit | null | no hit | null | no hit | null | hit | 200 | hit | 3.95 | no hit | null | no hit | null | no hit | null | null | no hit | no hit | null | null | 0.571 | null |
1a602e62 | null | 7 | AaH II; AaH I; LqhIII | single domain | 77 | SSEEELFEQIKKAILEAIKKRSKEEVVETIVEQLKSLGLEEEAEELREKVEKAKTDEEAAEILAEALMKMLKHRELL | null | null | null | no hit | null | null | null | no hit | null | no hit | null | no hit | null | no hit | null | no hit | null | no hit | null | null | no hit | no hit | null | null | null | null |
4eae42fc | null | 7 | AaH II; AaH I; LqhIII | single domain | 74 | NPEEWAKRYLEVLKKAKEDPSILEEALETSRRNQASPESIETIERMLEAIKAKDYAEFEKIFIDNLEPPVRAAL | null | null | null | no hit | null | null | null | no hit | null | no hit | null | hit | 955 | no hit | null | no hit | null | no hit | null | null | no hit | no hit | null | null | 0.395 | null |
End of preview. Expand in Data Studio
Scorpion toxin binder design: data release
Claude designed proteins de novo to bind five scorpion toxins: Cn2, Ts1, AaH II, AaH I, and LqhIII. Two contract research organizations measured binding by surface plasmon resonance (SPR): Adaptyv Bio and Twist Bioscience. Seventeen designs are binders: seven against Cn2, four against AaH II, four against AaH I, two against LqhIII, and none against Ts1. Report: De novo design of protein binders against scorpion toxins with Claude (https://www-cdn.anthropic.com/31ac578806cffd8b3d92d8affe6edc4c04d502e1.pdf). Blog post: https://www.anthropic.com/research/claude-scorpion-toxin-binder-design.
How the scorpion neurotoxin Cn2 acts on sodium channels, how the antibody LR neutralizes it, and how Cn2-B1 competed with LR for Cn2 (60 s, no sound). That Cn2-B1 should neutralize Cn2 as LR does is an expected outcome, not yet tested by patch-clamp recordings in cells.
Start here
design.csv has one row per design: sequence, each lab's result and KD against each toxin, and binder_against. Designs go by eight-character identifiers (uuid), binders also by names (Cn2-B1). Load uuid as text: a spreadsheet turns 946282e8 into 9.46E+13.
Dataset viewer
The default subset is design (one row per design, 211 rows). Every other top-level table and every table in supporting_tables/ is a subset named after its file; the two indexes are sensorgrams_index and structures_index; each subset has one split, full. The per-design folders in sensorgrams/ and structures/ are files to browse or download, as is the film in assets/.
What is in the package
| File or folder | Contents |
|---|---|
design.csv |
All 211 designs, with both labs' results and binder_against. |
in_silico_scores.csv |
Predicted scores, in the order of design.csv. |
Cn2_competition_Twist_Bioscience.csv |
Competition with the antibodies LR, RU1, and 9004G for Cn2: 16 designs and four controls. |
BVP_ELISA.csv |
Baculovirus particle (BVP) ELISA for polyreactivity: 51 designs. |
toxins.csv |
The five toxins: sequence, family, and design target. |
controls.csv |
The control antibodies at both labs: main screen and reverse BLI. |
sensorgrams/ |
One folder per design and control: picture, traces, and kinetic fits of the main screen, and the follow-up assays where run, indexed in INDEX.csv. |
structures/ |
One folder per design: design model and predicted structures, indexed in INDEX.csv. |
supporting_tables/ |
Twelve tables: how each design was made and expressed; follow-up assays; per-seed scores, interfaces, and thresholds (list in COLUMNS.md). |
COLUMNS.md |
Every file and every column, explained. |
LICENSE.md |
CC BY 4.0. |
Getting started
from datasets import load_dataset
import pandas as pd
designs = load_dataset("Anthropic/scorpion-toxin-binder-design", split="full") # the default subset, design.csv
origin = load_dataset("Anthropic/scorpion-toxin-binder-design", "origin", split="full") # any other subset by its name
table = pd.read_csv("hf://datasets/Anthropic/scorpion-toxin-binder-design/design.csv", dtype={"uuid": str}) # uuid as text
# the tables only
hf download Anthropic/scorpion-toxin-binder-design --repo-type dataset --include "*.csv" --exclude "sensorgrams/*/*"
# the two folders of one design (888c8f04 is Cn2-B1)
hf download Anthropic/scorpion-toxin-binder-design --repo-type dataset --include "*/888c8f04/*"
Terms, in the report's words
- We define a hit as a result at one lab indicating that a design binds a toxin or an unrelated protein (CLEC12A or OVA; off-target binding). The design, or the design-toxin pair, is then a hit at that lab.
- We define a binder of a toxin as a design with 1) a hit against the toxin at both labs, in every replicate, 2) every KD from the main screen at 1 µM or tighter, 3) a fitted maximum response (fitted Rmax) at Twist Bioscience within the theoretical Rmax (the largest response that one toxin molecule per binding site can give), and 4) no signal above background against CLEC12A in either of Twist Bioscience's two SPR runs. For LqhIII, measured only at Adaptyv Bio, a binder needed a hit there in every replicate, a KD of 1 µM or tighter, and criterion 4.
How to cite
Claude Science, Nathaniel Horwitz, James van Geelen, Kat Kajderowicz, Amir Shanehsazzadeh. De novo design of protein binders against scorpion toxins with Claude. October 20, 2026. https://www-cdn.anthropic.com/31ac578806cffd8b3d92d8affe6edc4c04d502e1.pdf.
License
CC BY 4.0 (see LICENSE.md).
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